BindingDB PrimarySearch

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SMILES: [H][C@]12[#6]-[#6]-[#6](=[#6])-[#6@@H](-[#6]\[#6]=[#6]-3/[#6@@H](-[#6]-[#8]-[#6]-3=O)-[#8]-[#6](-[#6])=O)[C@]1([#6])[#6]-[#6]-[#6](=O)[C@@]2([#6])[#6]-[#8][Si;v4]([#6])([#6])C([#6])([#6])[#6]

InChI Key: InChIKey=SCPKTCVWVMYYAV-DQVLGKLOSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50450176
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50450176 (CHEMBL4168778) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	4.57E+3	n/a	n/a	n/a	n/a
University of Macau Curated by ChEMBL					Assay Description Inhibition of NF-kappaB stimulated STAT3 activation in human HeLa cells incubated with NF-kappaB for 16 hrs followed by compound addition measured af...				Bioorg Med Chem 26: 5053-5061 (2018) Article DOI: 10.1016/j.bmc.2018.09.002 BindingDB Entry DOI: 10.7270/Q2ST7SDK
University of Macau Curated by ChEMBL					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50450176 (CHEMBL4168778) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	4.43E+3	n/a	n/a	n/a	n/a
University of Macau Curated by ChEMBL					Assay Description Inhibition of IFNgamma-stimulated STAT3 activation in human HeLa cells incubated with IFNgamma for 16 hrs followed by compound addition measured afte...				Bioorg Med Chem 26: 5053-5061 (2018) Article DOI: 10.1016/j.bmc.2018.09.002 BindingDB Entry DOI: 10.7270/Q2ST7SDK
University of Macau Curated by ChEMBL					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50450176 (CHEMBL4168778) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	990	n/a	n/a	n/a	n/a
University of Macau Curated by ChEMBL					Assay Description Inhibition of IL-6 stimulated STAT3 activation in human AD293 cells incubated with IL-6 for 16 hrs followed by compound addition measured after 6 hrs...				Bioorg Med Chem 26: 5053-5061 (2018) Article DOI: 10.1016/j.bmc.2018.09.002 BindingDB Entry DOI: 10.7270/Q2ST7SDK
University of Macau Curated by ChEMBL					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50450176 (CHEMBL4168778) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	7.52E+3	n/a	n/a	n/a	n/a
University of Macau Curated by ChEMBL					Assay Description Inhibition of NF-kappaB stimulated STAT3 activation in human AD293 cells incubated with NF-kappaB for 16 hrs followed by compound addition measured a...				Bioorg Med Chem 26: 5053-5061 (2018) Article DOI: 10.1016/j.bmc.2018.09.002 BindingDB Entry DOI: 10.7270/Q2ST7SDK
University of Macau Curated by ChEMBL					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50450176 (CHEMBL4168778) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.97E+3	n/a	n/a	n/a	n/a
University of Macau Curated by ChEMBL					Assay Description Inhibition of IFNgamma-stimulated STAT3 activation in human AD293 cells incubated with IFNgamma for 16 hrs followed by compound addition measured aft...				Bioorg Med Chem 26: 5053-5061 (2018) Article DOI: 10.1016/j.bmc.2018.09.002 BindingDB Entry DOI: 10.7270/Q2ST7SDK
University of Macau Curated by ChEMBL					More data for this Ligand-Target Pair