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SMILES: FC(F)(F)c1cccc2n3C[C@@]4(CN5CCC4CC5)Oc3nc12

InChI Key: InChIKey=GZGMORZIUKXWJK-OAHLLOKOSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50451605   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50451605 (CHEMBL4216282) Show SMILES FC(F)(F)c1cccc2n3C[C@@]4(CN5CCC4CC5)Oc3nc12 |r,wU:11.20,THB:19:11:14.15:18.17,(21.31,-17.57,;22.72,-18.38,;22.72,-16.76,;24.29,-17.96,;22.32,-19.95,;23.42,-21.04,;23.02,-22.53,;21.54,-22.93,;20.44,-21.85,;18.91,-21.94,;17.71,-22.9,;16.43,-22.07,;16.73,-23.54,;15.29,-22.87,;13.68,-23.57,;13.47,-22.11,;15.02,-21.44,;15.08,-19.72,;15.56,-20.88,;16.82,-20.59,;18.35,-20.5,;19.54,-19.53,;20.83,-20.36,)| Show InChI InChI=1S/C16H16F3N3O/c17-16(18,19)11-2-1-3-12-13(11)20-14-22(12)9-15(23-14)8-21-6-4-10(15)5-7-21/h1-3,10H,4-9H2/t15-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	22	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Agonist activity at rat alpha7 nAChR expressed in HEK293 cells co-expressing human RIC-3 assessed as increase in calcium flux measured for 2 mins by ...				Bioorg Med Chem Lett 27: 5002-5005 (2017) Article DOI: 10.1016/j.bmcl.2017.10.009 BindingDB Entry DOI: 10.7270/Q24Q7XJ3
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 3A (Homo sapiens (Human))	BDBM50451605 (CHEMBL4216282) Show SMILES FC(F)(F)c1cccc2n3C[C@@]4(CN5CCC4CC5)Oc3nc12 |r,wU:11.20,THB:19:11:14.15:18.17,(21.31,-17.57,;22.72,-18.38,;22.72,-16.76,;24.29,-17.96,;22.32,-19.95,;23.42,-21.04,;23.02,-22.53,;21.54,-22.93,;20.44,-21.85,;18.91,-21.94,;17.71,-22.9,;16.43,-22.07,;16.73,-23.54,;15.29,-22.87,;13.68,-23.57,;13.47,-22.11,;15.02,-21.44,;15.08,-19.72,;15.56,-20.88,;16.82,-20.59,;18.35,-20.5,;19.54,-19.53,;20.83,-20.36,)| Show InChI InChI=1S/C16H16F3N3O/c17-16(18,19)11-2-1-3-12-13(11)20-14-22(12)9-15(23-14)8-21-6-4-10(15)5-7-21/h1-3,10H,4-9H2/t15-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human 5-HT3A receptor expressed in HEK293 cells assessed as inhibition of 5-HT-induced calcium flux preincubated for 30 mins p...				Bioorg Med Chem Lett 27: 5002-5005 (2017) Article DOI: 10.1016/j.bmcl.2017.10.009 BindingDB Entry DOI: 10.7270/Q24Q7XJ3
					More data for this Ligand-Target Pair