BDBM50451616 CHEMBL4209782

SMILES: Cc1ccc2nc3O[C@@]4(Cn3c2c1)CN1CCC4CC1

InChI Key: InChIKey=RHRREOBZRURQPS-MRXNPFEDSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50451616   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-hydroxytryptamine receptor 3A (Homo sapiens (Human))	BDBM50451616 (CHEMBL4209782) Show SMILES Cc1ccc2nc3O[C@@]4(Cn3c2c1)CN1CCC4CC1 |r,wU:8.7,THB:7:8:15.16:19.18,(21.72,-23.36,;20.57,-22.22,;20.96,-20.73,;19.86,-19.64,;18.38,-20.05,;17.09,-19.22,;15.9,-20.19,;14.36,-20.28,;13.98,-21.76,;15.26,-22.59,;16.46,-21.63,;17.99,-21.54,;19.09,-22.63,;14.28,-23.23,;12.84,-22.56,;11.22,-23.26,;11.01,-21.8,;12.56,-21.13,;12.63,-19.41,;13.11,-20.57,)| Show InChI InChI=1S/C16H19N3O/c1-11-2-3-13-14(8-11)19-10-16(20-15(19)17-13)9-18-6-4-12(16)5-7-18/h2-3,8,12H,4-7,9-10H2,1H3/t16-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human 5-HT3A receptor expressed in HEK293 cells assessed as inhibition of 5-HT-induced calcium flux preincubated for 30 mins p...				Bioorg Med Chem Lett 27: 5002-5005 (2017) Article DOI: 10.1016/j.bmcl.2017.10.009 BindingDB Entry DOI: 10.7270/Q24Q7XJ3
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50451616 (CHEMBL4209782) Show SMILES Cc1ccc2nc3O[C@@]4(Cn3c2c1)CN1CCC4CC1 |r,wU:8.7,THB:7:8:15.16:19.18,(21.72,-23.36,;20.57,-22.22,;20.96,-20.73,;19.86,-19.64,;18.38,-20.05,;17.09,-19.22,;15.9,-20.19,;14.36,-20.28,;13.98,-21.76,;15.26,-22.59,;16.46,-21.63,;17.99,-21.54,;19.09,-22.63,;14.28,-23.23,;12.84,-22.56,;11.22,-23.26,;11.01,-21.8,;12.56,-21.13,;12.63,-19.41,;13.11,-20.57,)| Show InChI InChI=1S/C16H19N3O/c1-11-2-3-13-14(8-11)19-10-16(20-15(19)17-13)9-18-6-4-12(16)5-7-18/h2-3,8,12H,4-7,9-10H2,1H3/t16-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	33	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Agonist activity at rat alpha7 nAChR expressed in HEK293 cells co-expressing human RIC-3 assessed as increase in calcium flux measured for 2 mins by ...				Bioorg Med Chem Lett 27: 5002-5005 (2017) Article DOI: 10.1016/j.bmcl.2017.10.009 BindingDB Entry DOI: 10.7270/Q24Q7XJ3
					More data for this Ligand-Target Pair