BDBM50452452 CHEMBL4204379

SMILES: C[C@H](CO)Nc1nc(N[C@H]2CC[C@@H](CC2)NC(=O)N2CC(O)C2)c2cc(ccc2n1)-c1cccc(F)c1

InChI Key: InChIKey=BUSKWJWGVXSNQM-MAODMQOUSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50452452   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Atrial natriuretic peptide receptor (Homo sapiens (Human))	BDBM50452452 (CHEMBL4204379) Show SMILES C[C@H](CO)Nc1nc(N[C@H]2CC[C@@H](CC2)NC(=O)N2CC(O)C2)c2cc(ccc2n1)-c1cccc(F)c1 |r,wU:9.8,1.0,wD:12.15,(67.01,-7.35,;67.02,-5.82,;68.34,-5.07,;69.66,-5.85,;65.7,-5.06,;64.37,-5.82,;64.36,-7.36,;63.02,-8.12,;63.01,-9.66,;64.34,-10.44,;65.68,-9.68,;67.01,-10.45,;67,-11.99,;65.66,-12.76,;64.33,-11.98,;68.33,-12.77,;69.66,-12.01,;69.67,-10.49,;70.98,-12.78,;71.36,-14.26,;72.84,-13.88,;74.16,-14.65,;72.45,-12.4,;61.69,-7.34,;60.36,-8.11,;59.02,-7.33,;59.03,-5.79,;60.37,-5.03,;61.7,-5.8,;63.04,-5.04,;57.68,-8.1,;57.68,-9.64,;56.34,-10.4,;55.01,-9.62,;55.02,-8.08,;53.69,-7.31,;56.35,-7.32,)| Show InChI InChI=1S/C27H33FN6O3/c1-16(15-35)29-26-32-24-10-5-18(17-3-2-4-19(28)11-17)12-23(24)25(33-26)30-20-6-8-21(9-7-20)31-27(37)34-13-22(36)14-34/h2-5,10-12,16,20-22,35-36H,6-9,13-15H2,1H3,(H,31,37)(H2,29,30,32,33)/t16-,20-,21-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	420	n/a	n/a	n/a	n/a
Asubio Pharma Co., Ltd Curated by ChEMBL					Assay Description Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay				Bioorg Med Chem 25: 6680-6694 (2017) Article DOI: 10.1016/j.bmc.2017.11.006 BindingDB Entry DOI: 10.7270/Q2ZW1PG6
					More data for this Ligand-Target Pair
Atrial natriuretic peptide receptor 1 (Rattus norvegicus)	BDBM50452452 (CHEMBL4204379) Show SMILES C[C@H](CO)Nc1nc(N[C@H]2CC[C@@H](CC2)NC(=O)N2CC(O)C2)c2cc(ccc2n1)-c1cccc(F)c1 |r,wU:9.8,1.0,wD:12.15,(67.01,-7.35,;67.02,-5.82,;68.34,-5.07,;69.66,-5.85,;65.7,-5.06,;64.37,-5.82,;64.36,-7.36,;63.02,-8.12,;63.01,-9.66,;64.34,-10.44,;65.68,-9.68,;67.01,-10.45,;67,-11.99,;65.66,-12.76,;64.33,-11.98,;68.33,-12.77,;69.66,-12.01,;69.67,-10.49,;70.98,-12.78,;71.36,-14.26,;72.84,-13.88,;74.16,-14.65,;72.45,-12.4,;61.69,-7.34,;60.36,-8.11,;59.02,-7.33,;59.03,-5.79,;60.37,-5.03,;61.7,-5.8,;63.04,-5.04,;57.68,-8.1,;57.68,-9.64,;56.34,-10.4,;55.01,-9.62,;55.02,-8.08,;53.69,-7.31,;56.35,-7.32,)| Show InChI InChI=1S/C27H33FN6O3/c1-16(15-35)29-26-32-24-10-5-18(17-3-2-4-19(28)11-17)12-23(24)25(33-26)30-20-6-8-21(9-7-20)31-27(37)34-13-22(36)14-34/h2-5,10-12,16,20-22,35-36H,6-9,13-15H2,1H3,(H,31,37)(H2,29,30,32,33)/t16-,20-,21-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	900	n/a	n/a	n/a	n/a
Asubio Pharma Co., Ltd Curated by ChEMBL					Assay Description Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay				Bioorg Med Chem 25: 6680-6694 (2017) Article DOI: 10.1016/j.bmc.2017.11.006 BindingDB Entry DOI: 10.7270/Q2ZW1PG6
					More data for this Ligand-Target Pair