BDBM50452458 CHEMBL4207138

SMILES: C[C@H](CO)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)NC2(CO)CCCC2)c2cc(ccc2n1)-c1cccc(F)c1

InChI Key: InChIKey=RMGPQXNQAAUOOB-FOVJLYNBSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50452458   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Atrial natriuretic peptide receptor (Homo sapiens (Human))	BDBM50452458 (CHEMBL4207138) Show SMILES C[C@H](CO)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)NC2(CO)CCCC2)c2cc(ccc2n1)-c1cccc(F)c1 |r,wU:9.8,12.15,1.0,(15.1,-7.02,;15.11,-5.48,;16.44,-4.72,;17.76,-5.49,;13.79,-4.72,;12.45,-5.48,;12.45,-7.02,;11.11,-7.78,;11.1,-9.32,;12.43,-10.1,;12.42,-11.64,;13.75,-12.42,;15.09,-11.65,;15.1,-10.11,;13.77,-9.34,;16.42,-12.43,;17.75,-11.67,;17.76,-10.15,;19.07,-12.45,;20.41,-11.68,;21.73,-12.46,;23.06,-11.7,;21.63,-10.74,;21.11,-9.29,;19.58,-9.33,;19.14,-10.81,;9.78,-7,;8.44,-7.77,;7.11,-6.99,;7.12,-5.45,;8.46,-4.69,;9.79,-5.46,;11.12,-4.7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.11,-7.74,;1.78,-6.97,;4.44,-6.98,)| Show InChI InChI=1S/C30H39FN6O3/c1-19(17-38)32-28-35-26-12-7-21(20-5-4-6-22(31)15-20)16-25(26)27(36-28)33-23-8-10-24(11-9-23)34-29(40)37-30(18-39)13-2-3-14-30/h4-7,12,15-16,19,23-24,38-39H,2-3,8-11,13-14,17-18H2,1H3,(H2,34,37,40)(H2,32,33,35,36)/t19-,23-,24+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	78	n/a	n/a	n/a	n/a
Asubio Pharma Co., Ltd Curated by ChEMBL					Assay Description Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay				Bioorg Med Chem 25: 6680-6694 (2017) Article DOI: 10.1016/j.bmc.2017.11.006 BindingDB Entry DOI: 10.7270/Q2ZW1PG6
					More data for this Ligand-Target Pair
Atrial natriuretic peptide receptor 1 (Rattus norvegicus)	BDBM50452458 (CHEMBL4207138) Show SMILES C[C@H](CO)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)NC2(CO)CCCC2)c2cc(ccc2n1)-c1cccc(F)c1 |r,wU:9.8,12.15,1.0,(15.1,-7.02,;15.11,-5.48,;16.44,-4.72,;17.76,-5.49,;13.79,-4.72,;12.45,-5.48,;12.45,-7.02,;11.11,-7.78,;11.1,-9.32,;12.43,-10.1,;12.42,-11.64,;13.75,-12.42,;15.09,-11.65,;15.1,-10.11,;13.77,-9.34,;16.42,-12.43,;17.75,-11.67,;17.76,-10.15,;19.07,-12.45,;20.41,-11.68,;21.73,-12.46,;23.06,-11.7,;21.63,-10.74,;21.11,-9.29,;19.58,-9.33,;19.14,-10.81,;9.78,-7,;8.44,-7.77,;7.11,-6.99,;7.12,-5.45,;8.46,-4.69,;9.79,-5.46,;11.12,-4.7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.11,-7.74,;1.78,-6.97,;4.44,-6.98,)| Show InChI InChI=1S/C30H39FN6O3/c1-19(17-38)32-28-35-26-12-7-21(20-5-4-6-22(31)15-20)16-25(26)27(36-28)33-23-8-10-24(11-9-23)34-29(40)37-30(18-39)13-2-3-14-30/h4-7,12,15-16,19,23-24,38-39H,2-3,8-11,13-14,17-18H2,1H3,(H2,34,37,40)(H2,32,33,35,36)/t19-,23-,24+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	120	n/a	n/a	n/a	n/a
Asubio Pharma Co., Ltd Curated by ChEMBL					Assay Description Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay				Bioorg Med Chem 25: 6680-6694 (2017) Article DOI: 10.1016/j.bmc.2017.11.006 BindingDB Entry DOI: 10.7270/Q2ZW1PG6
					More data for this Ligand-Target Pair