BDBM50452460 CHEMBL4218972

SMILES: CC(C)NC(=O)N[C@H]1CC[C@H](CC1)Nc1nc(nc2ccc(cc12)-c1cccc(F)c1)N(C)CCO

InChI Key: InChIKey=URYNZEZTILJOEU-SZPZYZBQSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50452460   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Atrial natriuretic peptide receptor (Homo sapiens (Human))	BDBM50452460 (CHEMBL4218972) Show SMILES CC(C)NC(=O)N[C@H]1CC[C@H](CC1)Nc1nc(nc2ccc(cc12)-c1cccc(F)c1)N(C)CCO |r,wU:10.13,7.6,(21.73,-12.46,;20.4,-11.68,;20.41,-10.15,;19.07,-12.44,;17.75,-11.67,;17.75,-10.15,;16.41,-12.43,;15.09,-11.65,;13.75,-12.42,;12.42,-11.64,;12.43,-10.1,;13.77,-9.34,;15.09,-10.11,;11.1,-9.32,;11.11,-7.78,;12.44,-7.02,;12.45,-5.48,;11.12,-4.7,;9.79,-5.46,;8.46,-4.69,;7.11,-5.45,;7.11,-6.99,;8.44,-7.77,;9.78,-7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.1,-7.74,;1.78,-6.97,;4.44,-6.98,;13.79,-4.72,;13.8,-3.18,;15.1,-5.48,;16.43,-4.73,;17.75,-5.51,)| Show InChI InChI=1S/C27H35FN6O2/c1-17(2)29-27(36)31-22-10-8-21(9-11-22)30-25-23-16-19(18-5-4-6-20(28)15-18)7-12-24(23)32-26(33-25)34(3)13-14-35/h4-7,12,15-17,21-22,35H,8-11,13-14H2,1-3H3,(H2,29,31,36)(H,30,32,33)/t21-,22+	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	720	n/a	n/a	n/a	n/a
Asubio Pharma Co., Ltd Curated by ChEMBL					Assay Description Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay				Bioorg Med Chem 25: 6680-6694 (2017) Article DOI: 10.1016/j.bmc.2017.11.006 BindingDB Entry DOI: 10.7270/Q2ZW1PG6
					More data for this Ligand-Target Pair
Atrial natriuretic peptide receptor 1 (Rattus norvegicus)	BDBM50452460 (CHEMBL4218972) Show SMILES CC(C)NC(=O)N[C@H]1CC[C@H](CC1)Nc1nc(nc2ccc(cc12)-c1cccc(F)c1)N(C)CCO |r,wU:10.13,7.6,(21.73,-12.46,;20.4,-11.68,;20.41,-10.15,;19.07,-12.44,;17.75,-11.67,;17.75,-10.15,;16.41,-12.43,;15.09,-11.65,;13.75,-12.42,;12.42,-11.64,;12.43,-10.1,;13.77,-9.34,;15.09,-10.11,;11.1,-9.32,;11.11,-7.78,;12.44,-7.02,;12.45,-5.48,;11.12,-4.7,;9.79,-5.46,;8.46,-4.69,;7.11,-5.45,;7.11,-6.99,;8.44,-7.77,;9.78,-7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.1,-7.74,;1.78,-6.97,;4.44,-6.98,;13.79,-4.72,;13.8,-3.18,;15.1,-5.48,;16.43,-4.73,;17.75,-5.51,)| Show InChI InChI=1S/C27H35FN6O2/c1-17(2)29-27(36)31-22-10-8-21(9-11-22)30-25-23-16-19(18-5-4-6-20(28)15-18)7-12-24(23)32-26(33-25)34(3)13-14-35/h4-7,12,15-17,21-22,35H,8-11,13-14H2,1-3H3,(H2,29,31,36)(H,30,32,33)/t21-,22+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a
Asubio Pharma Co., Ltd Curated by ChEMBL					Assay Description Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay				Bioorg Med Chem 25: 6680-6694 (2017) Article DOI: 10.1016/j.bmc.2017.11.006 BindingDB Entry DOI: 10.7270/Q2ZW1PG6
					More data for this Ligand-Target Pair