BDBM50452461 CHEMBL4214047

SMILES: COCCNc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)NC(C)C)c2cc(ccc2n1)-c1cccc(F)c1

InChI Key: InChIKey=JTGSJAPEPMOZOM-SZPZYZBQSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50452461   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Atrial natriuretic peptide receptor (Homo sapiens (Human))	BDBM50452461 (CHEMBL4214047) Show SMILES COCCNc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)NC(C)C)c2cc(ccc2n1)-c1cccc(F)c1 |r,wU:9.8,12.15,(19.08,-4.75,;17.75,-5.51,;16.43,-4.73,;15.1,-5.48,;13.79,-4.72,;12.45,-5.48,;12.44,-7.02,;11.11,-7.78,;11.1,-9.32,;12.43,-10.1,;12.42,-11.64,;13.75,-12.42,;15.09,-11.65,;15.09,-10.11,;13.77,-9.34,;16.41,-12.43,;17.75,-11.67,;17.75,-10.15,;19.07,-12.44,;20.4,-11.68,;21.73,-12.46,;20.41,-10.15,;9.78,-7,;8.44,-7.77,;7.11,-6.99,;7.11,-5.45,;8.46,-4.69,;9.79,-5.46,;11.12,-4.7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.1,-7.74,;1.78,-6.97,;4.44,-6.98,)| Show InChI InChI=1S/C27H35FN6O2/c1-17(2)30-27(35)32-22-10-8-21(9-11-22)31-25-23-16-19(18-5-4-6-20(28)15-18)7-12-24(23)33-26(34-25)29-13-14-36-3/h4-7,12,15-17,21-22H,8-11,13-14H2,1-3H3,(H2,30,32,35)(H2,29,31,33,34)/t21-,22+	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	380	n/a	n/a	n/a	n/a
Asubio Pharma Co., Ltd Curated by ChEMBL					Assay Description Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay				Bioorg Med Chem 25: 6680-6694 (2017) Article DOI: 10.1016/j.bmc.2017.11.006 BindingDB Entry DOI: 10.7270/Q2ZW1PG6
					More data for this Ligand-Target Pair
Atrial natriuretic peptide receptor 1 (Rattus norvegicus)	BDBM50452461 (CHEMBL4214047) Show SMILES COCCNc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)NC(C)C)c2cc(ccc2n1)-c1cccc(F)c1 |r,wU:9.8,12.15,(19.08,-4.75,;17.75,-5.51,;16.43,-4.73,;15.1,-5.48,;13.79,-4.72,;12.45,-5.48,;12.44,-7.02,;11.11,-7.78,;11.1,-9.32,;12.43,-10.1,;12.42,-11.64,;13.75,-12.42,;15.09,-11.65,;15.09,-10.11,;13.77,-9.34,;16.41,-12.43,;17.75,-11.67,;17.75,-10.15,;19.07,-12.44,;20.4,-11.68,;21.73,-12.46,;20.41,-10.15,;9.78,-7,;8.44,-7.77,;7.11,-6.99,;7.11,-5.45,;8.46,-4.69,;9.79,-5.46,;11.12,-4.7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.1,-7.74,;1.78,-6.97,;4.44,-6.98,)| Show InChI InChI=1S/C27H35FN6O2/c1-17(2)30-27(35)32-22-10-8-21(9-11-22)31-25-23-16-19(18-5-4-6-20(28)15-18)7-12-24(23)33-26(34-25)29-13-14-36-3/h4-7,12,15-17,21-22H,8-11,13-14H2,1-3H3,(H2,30,32,35)(H2,29,31,33,34)/t21-,22+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	610	n/a	n/a	n/a	n/a
Asubio Pharma Co., Ltd Curated by ChEMBL					Assay Description Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay				Bioorg Med Chem 25: 6680-6694 (2017) Article DOI: 10.1016/j.bmc.2017.11.006 BindingDB Entry DOI: 10.7270/Q2ZW1PG6
					More data for this Ligand-Target Pair