BDBM50452466 CHEMBL4205825

SMILES: C[C@H](CO)Nc1nc(N[C@H]2CC[C@@H](CC2)NC(=O)[C@H]2C[C@H](O)C2)c2cc(ccc2n1)-c1cccc(F)c1

InChI Key: InChIKey=SACXNNLVISVGPL-OESNXZKLSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50452466   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Atrial natriuretic peptide receptor (Homo sapiens (Human))	BDBM50452466 (CHEMBL4205825) Show SMILES C[C@H](CO)Nc1nc(N[C@H]2CC[C@@H](CC2)NC(=O)[C@H]2C[C@H](O)C2)c2cc(ccc2n1)-c1cccc(F)c1 |r,wU:9.8,1.0,20.21,wD:12.15,18.18,(45.91,-35.08,;45.92,-33.55,;47.24,-32.8,;48.56,-33.58,;44.6,-32.79,;43.27,-33.55,;43.26,-35.09,;41.92,-35.85,;41.91,-37.39,;43.24,-38.17,;44.58,-37.41,;45.91,-38.18,;45.9,-39.72,;44.56,-40.49,;43.23,-39.71,;47.23,-40.5,;48.56,-39.74,;48.57,-38.22,;49.88,-40.52,;50.26,-41.99,;51.74,-41.61,;53.06,-42.38,;51.35,-40.13,;40.59,-35.07,;39.26,-35.84,;37.92,-35.06,;37.93,-33.52,;39.27,-32.76,;40.6,-33.53,;41.94,-32.77,;36.58,-35.83,;36.57,-37.37,;35.24,-38.13,;33.91,-37.35,;33.92,-35.81,;32.59,-35.04,;35.25,-35.05,)| Show InChI InChI=1S/C28H34FN5O3/c1-16(15-35)30-28-33-25-10-5-18(17-3-2-4-20(29)11-17)14-24(25)26(34-28)31-21-6-8-22(9-7-21)32-27(37)19-12-23(36)13-19/h2-5,10-11,14,16,19,21-23,35-36H,6-9,12-13,15H2,1H3,(H,32,37)(H2,30,31,33,34)/t16-,19-,21-,22-,23-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	470	n/a	n/a	n/a	n/a
Asubio Pharma Co., Ltd Curated by ChEMBL					Assay Description Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay				Bioorg Med Chem 25: 6680-6694 (2017) Article DOI: 10.1016/j.bmc.2017.11.006 BindingDB Entry DOI: 10.7270/Q2ZW1PG6
					More data for this Ligand-Target Pair
Atrial natriuretic peptide receptor 1 (Rattus norvegicus)	BDBM50452466 (CHEMBL4205825) Show SMILES C[C@H](CO)Nc1nc(N[C@H]2CC[C@@H](CC2)NC(=O)[C@H]2C[C@H](O)C2)c2cc(ccc2n1)-c1cccc(F)c1 |r,wU:9.8,1.0,20.21,wD:12.15,18.18,(45.91,-35.08,;45.92,-33.55,;47.24,-32.8,;48.56,-33.58,;44.6,-32.79,;43.27,-33.55,;43.26,-35.09,;41.92,-35.85,;41.91,-37.39,;43.24,-38.17,;44.58,-37.41,;45.91,-38.18,;45.9,-39.72,;44.56,-40.49,;43.23,-39.71,;47.23,-40.5,;48.56,-39.74,;48.57,-38.22,;49.88,-40.52,;50.26,-41.99,;51.74,-41.61,;53.06,-42.38,;51.35,-40.13,;40.59,-35.07,;39.26,-35.84,;37.92,-35.06,;37.93,-33.52,;39.27,-32.76,;40.6,-33.53,;41.94,-32.77,;36.58,-35.83,;36.57,-37.37,;35.24,-38.13,;33.91,-37.35,;33.92,-35.81,;32.59,-35.04,;35.25,-35.05,)| Show InChI InChI=1S/C28H34FN5O3/c1-16(15-35)30-28-33-25-10-5-18(17-3-2-4-20(29)11-17)14-24(25)26(34-28)31-21-6-8-22(9-7-21)32-27(37)19-12-23(36)13-19/h2-5,10-11,14,16,19,21-23,35-36H,6-9,12-13,15H2,1H3,(H,32,37)(H2,30,31,33,34)/t16-,19-,21-,22-,23-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	700	n/a	n/a	n/a	n/a
Asubio Pharma Co., Ltd Curated by ChEMBL					Assay Description Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay				Bioorg Med Chem 25: 6680-6694 (2017) Article DOI: 10.1016/j.bmc.2017.11.006 BindingDB Entry DOI: 10.7270/Q2ZW1PG6
					More data for this Ligand-Target Pair