Found 2 hits for monomerid = 50452467 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Atrial natriuretic peptide receptor
(Homo sapiens (Human)) | BDBM50452467
(CHEMBL4218032)Show SMILES CC(C)N[C@H]1C[C@@H](C1)C(=O)N[C@H]1CC[C@@H](CC1)Nc1nc(N[C@H](C)CO)nc2ccc(cc12)-c1ccccc1 |r,wU:14.18,22.24,4.3,wD:11.11,6.8,(53.52,-15.72,;52.19,-14.94,;52.21,-13.41,;50.86,-15.7,;49.53,-14.92,;48.05,-15.31,;47.67,-13.83,;49.15,-13.44,;46.35,-13.06,;46.36,-11.53,;45.02,-13.82,;43.69,-13.04,;43.69,-11.49,;42.36,-10.72,;41.02,-11.48,;41.02,-13.02,;42.35,-13.8,;39.69,-10.71,;39.7,-9.16,;41.04,-8.39,;41.05,-6.85,;42.39,-6.09,;43.71,-6.86,;43.7,-8.39,;45.03,-6.1,;46.36,-6.88,;39.72,-6.08,;38.38,-6.84,;37.05,-6.06,;35.7,-6.82,;35.69,-8.37,;37.03,-9.15,;38.37,-8.38,;34.35,-9.14,;34.35,-10.68,;33.01,-11.44,;31.68,-10.66,;31.68,-9.12,;33.02,-8.35,)| Show InChI InChI=1S/C31H42N6O2/c1-19(2)32-26-15-23(16-26)30(39)35-25-12-10-24(11-13-25)34-29-27-17-22(21-7-5-4-6-8-21)9-14-28(27)36-31(37-29)33-20(3)18-38/h4-9,14,17,19-20,23-26,32,38H,10-13,15-16,18H2,1-3H3,(H,35,39)(H2,33,34,36,37)/t20-,23-,24-,25-,26-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 320 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006 BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Rattus norvegicus) | BDBM50452467
(CHEMBL4218032)Show SMILES CC(C)N[C@H]1C[C@@H](C1)C(=O)N[C@H]1CC[C@@H](CC1)Nc1nc(N[C@H](C)CO)nc2ccc(cc12)-c1ccccc1 |r,wU:14.18,22.24,4.3,wD:11.11,6.8,(53.52,-15.72,;52.19,-14.94,;52.21,-13.41,;50.86,-15.7,;49.53,-14.92,;48.05,-15.31,;47.67,-13.83,;49.15,-13.44,;46.35,-13.06,;46.36,-11.53,;45.02,-13.82,;43.69,-13.04,;43.69,-11.49,;42.36,-10.72,;41.02,-11.48,;41.02,-13.02,;42.35,-13.8,;39.69,-10.71,;39.7,-9.16,;41.04,-8.39,;41.05,-6.85,;42.39,-6.09,;43.71,-6.86,;43.7,-8.39,;45.03,-6.1,;46.36,-6.88,;39.72,-6.08,;38.38,-6.84,;37.05,-6.06,;35.7,-6.82,;35.69,-8.37,;37.03,-9.15,;38.37,-8.38,;34.35,-9.14,;34.35,-10.68,;33.01,-11.44,;31.68,-10.66,;31.68,-9.12,;33.02,-8.35,)| Show InChI InChI=1S/C31H42N6O2/c1-19(2)32-26-15-23(16-26)30(39)35-25-12-10-24(11-13-25)34-29-27-17-22(21-7-5-4-6-8-21)9-14-28(27)36-31(37-29)33-20(3)18-38/h4-9,14,17,19-20,23-26,32,38H,10-13,15-16,18H2,1-3H3,(H,35,39)(H2,33,34,36,37)/t20-,23-,24-,25-,26-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006 BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this Ligand-Target Pair | |