BDBM50452474 CHEMBL4217523

SMILES: C[C@H](CO)Nc1nc(N[C@H]2CC[C@@H](CC2)NC(=O)[C@H]2C[C@H](O)C2)c2cc(ccc2n1)-c1ccccc1

InChI Key: InChIKey=XKGVIGQUWRKHLV-BGJWJPPZSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50452474   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Atrial natriuretic peptide receptor (Homo sapiens (Human))	BDBM50452474 (CHEMBL4217523) Show SMILES C[C@H](CO)Nc1nc(N[C@H]2CC[C@@H](CC2)NC(=O)[C@H]2C[C@H](O)C2)c2cc(ccc2n1)-c1ccccc1 |r,wU:9.8,1.0,20.21,wD:12.15,18.18,(44.29,-21.96,;44.3,-20.44,;45.62,-19.68,;46.95,-20.46,;42.98,-19.67,;41.65,-20.43,;41.64,-21.97,;40.3,-22.74,;40.29,-24.28,;41.62,-25.05,;42.96,-24.29,;44.29,-25.06,;44.28,-26.6,;42.94,-27.37,;41.62,-26.59,;45.61,-27.38,;46.94,-26.62,;46.95,-25.1,;48.26,-27.4,;48.64,-28.87,;50.12,-28.49,;51.44,-29.27,;49.73,-27.01,;38.97,-21.96,;37.64,-22.72,;36.3,-21.94,;36.31,-20.4,;37.65,-19.64,;38.98,-20.42,;40.32,-19.66,;34.96,-22.71,;34.96,-24.25,;33.62,-25.01,;32.29,-24.24,;32.3,-22.7,;33.63,-21.93,)| Show InChI InChI=1S/C28H35N5O3/c1-17(16-34)29-28-32-25-12-7-19(18-5-3-2-4-6-18)15-24(25)26(33-28)30-21-8-10-22(11-9-21)31-27(36)20-13-23(35)14-20/h2-7,12,15,17,20-23,34-35H,8-11,13-14,16H2,1H3,(H,31,36)(H2,29,30,32,33)/t17-,20-,21-,22-,23-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	900	n/a	n/a	n/a	n/a
Asubio Pharma Co., Ltd Curated by ChEMBL					Assay Description Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay				Bioorg Med Chem 25: 6680-6694 (2017) Article DOI: 10.1016/j.bmc.2017.11.006 BindingDB Entry DOI: 10.7270/Q2ZW1PG6
					More data for this Ligand-Target Pair
Atrial natriuretic peptide receptor 1 (Rattus norvegicus)	BDBM50452474 (CHEMBL4217523) Show SMILES C[C@H](CO)Nc1nc(N[C@H]2CC[C@@H](CC2)NC(=O)[C@H]2C[C@H](O)C2)c2cc(ccc2n1)-c1ccccc1 |r,wU:9.8,1.0,20.21,wD:12.15,18.18,(44.29,-21.96,;44.3,-20.44,;45.62,-19.68,;46.95,-20.46,;42.98,-19.67,;41.65,-20.43,;41.64,-21.97,;40.3,-22.74,;40.29,-24.28,;41.62,-25.05,;42.96,-24.29,;44.29,-25.06,;44.28,-26.6,;42.94,-27.37,;41.62,-26.59,;45.61,-27.38,;46.94,-26.62,;46.95,-25.1,;48.26,-27.4,;48.64,-28.87,;50.12,-28.49,;51.44,-29.27,;49.73,-27.01,;38.97,-21.96,;37.64,-22.72,;36.3,-21.94,;36.31,-20.4,;37.65,-19.64,;38.98,-20.42,;40.32,-19.66,;34.96,-22.71,;34.96,-24.25,;33.62,-25.01,;32.29,-24.24,;32.3,-22.7,;33.63,-21.93,)| Show InChI InChI=1S/C28H35N5O3/c1-17(16-34)29-28-32-25-12-7-19(18-5-3-2-4-6-18)15-24(25)26(33-28)30-21-8-10-22(11-9-21)31-27(36)20-13-23(35)14-20/h2-7,12,15,17,20-23,34-35H,8-11,13-14,16H2,1H3,(H,31,36)(H2,29,30,32,33)/t17-,20-,21-,22-,23-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a
Asubio Pharma Co., Ltd Curated by ChEMBL					Assay Description Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay				Bioorg Med Chem 25: 6680-6694 (2017) Article DOI: 10.1016/j.bmc.2017.11.006 BindingDB Entry DOI: 10.7270/Q2ZW1PG6
					More data for this Ligand-Target Pair