Found 2 hits for monomerid = 50452475 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Atrial natriuretic peptide receptor 1
(Rattus norvegicus) | BDBM50452475
(CHEMBL4218179)Show SMILES CC(C)[C@@H](CO)NC(=O)N[C@H]1CC[C@H](CC1)Nc1nc(N[C@H](C)CO)nc2ccc(cc12)-c1cccc(F)c1 |r,wU:13.16,10.9,21.22,3.2,(21.75,-9.39,;20.42,-10.15,;19.1,-9.37,;20.41,-11.68,;21.73,-12.46,;23.06,-11.7,;19.07,-12.44,;17.75,-11.67,;17.76,-10.15,;16.42,-12.43,;15.09,-11.65,;13.75,-12.42,;12.42,-11.64,;12.43,-10.1,;13.77,-9.34,;15.09,-10.11,;11.1,-9.32,;11.11,-7.78,;12.45,-7.02,;12.45,-5.48,;13.79,-4.72,;15.11,-5.48,;15.1,-7.02,;16.44,-4.72,;17.76,-5.49,;11.12,-4.7,;9.79,-5.46,;8.46,-4.69,;7.11,-5.45,;7.11,-6.99,;8.44,-7.77,;9.78,-7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.11,-7.74,;1.78,-6.97,;4.44,-6.98,)| Show InChI InChI=1S/C29H39FN6O3/c1-17(2)26(16-38)35-29(39)33-23-10-8-22(9-11-23)32-27-24-14-20(19-5-4-6-21(30)13-19)7-12-25(24)34-28(36-27)31-18(3)15-37/h4-7,12-14,17-18,22-23,26,37-38H,8-11,15-16H2,1-3H3,(H2,33,35,39)(H2,31,32,34,36)/t18-,22-,23+,26-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 330 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006 BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this Ligand-Target Pair | |
Atrial natriuretic peptide receptor
(Homo sapiens (Human)) | BDBM50452475
(CHEMBL4218179)Show SMILES CC(C)[C@@H](CO)NC(=O)N[C@H]1CC[C@H](CC1)Nc1nc(N[C@H](C)CO)nc2ccc(cc12)-c1cccc(F)c1 |r,wU:13.16,10.9,21.22,3.2,(21.75,-9.39,;20.42,-10.15,;19.1,-9.37,;20.41,-11.68,;21.73,-12.46,;23.06,-11.7,;19.07,-12.44,;17.75,-11.67,;17.76,-10.15,;16.42,-12.43,;15.09,-11.65,;13.75,-12.42,;12.42,-11.64,;12.43,-10.1,;13.77,-9.34,;15.09,-10.11,;11.1,-9.32,;11.11,-7.78,;12.45,-7.02,;12.45,-5.48,;13.79,-4.72,;15.11,-5.48,;15.1,-7.02,;16.44,-4.72,;17.76,-5.49,;11.12,-4.7,;9.79,-5.46,;8.46,-4.69,;7.11,-5.45,;7.11,-6.99,;8.44,-7.77,;9.78,-7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.11,-7.74,;1.78,-6.97,;4.44,-6.98,)| Show InChI InChI=1S/C29H39FN6O3/c1-17(2)26(16-38)35-29(39)33-23-10-8-22(9-11-23)32-27-24-14-20(19-5-4-6-21(30)13-19)7-12-25(24)34-28(36-27)31-18(3)15-37/h4-7,12-14,17-18,22-23,26,37-38H,8-11,15-16H2,1-3H3,(H2,33,35,39)(H2,31,32,34,36)/t18-,22-,23+,26-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 41 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006 BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this Ligand-Target Pair | |