BDBM50452788 CHEMBL4206412
SMILES: CC1(C)CCN(c2ccc(cc12)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
InChI Key: InChIKey=IFPBFPWEKKDYCO-UHFFFAOYSA-N
Data: 4 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Oxysterols receptor LXR-alpha (Homo sapiens (Human)) | BDBM50452788 (CHEMBL4206412) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 290 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Curated by ChEMBL | Assay Description Agonist activity at GAL4-tagged human LXRalpha assessed as receptor activation expressed in African green monkey CV1 cells by luciferase reporter gen... | Bioorg Med Chem Lett 28: 85-93 (2018) Article DOI: 10.1016/j.bmcl.2017.12.006 BindingDB Entry DOI: 10.7270/Q2862K0Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Oxysterols receptor LXR-beta (Homo sapiens (Human)) | BDBM50452788 (CHEMBL4206412) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 550 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Curated by ChEMBL | Assay Description Agonist activity at GAL4-tagged human LXRbeta assessed as receptor activation expressed in African green monkey CV1 cells by luciferase reporter gene... | Bioorg Med Chem Lett 28: 85-93 (2018) Article DOI: 10.1016/j.bmcl.2017.12.006 BindingDB Entry DOI: 10.7270/Q2862K0Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pregnane X receptor (Homo sapiens (Human)) | BDBM50452788 (CHEMBL4206412) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 36 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Curated by ChEMBL | Assay Description Transactivation of PXR in human HepG2 cells by receptor transactivation assay | Bioorg Med Chem Lett 28: 85-93 (2018) Article DOI: 10.1016/j.bmcl.2017.12.006 BindingDB Entry DOI: 10.7270/Q2862K0Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM50452788 (CHEMBL4206412) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 815 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Curated by ChEMBL | Assay Description Inverse agonist activity at Gal4-tagged human RORgammat ligand binding domain expressed in human Jurkat cells by native IL17 promoter driven lucifera... | Bioorg Med Chem Lett 28: 85-93 (2018) Article DOI: 10.1016/j.bmcl.2017.12.006 BindingDB Entry DOI: 10.7270/Q2862K0Z | |||||||||||
More data for this Ligand-Target Pair |