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SMILES: Cc1noc(n1)[C@@H]1CCC(=O)N1c1cc(F)c(cc1F)-c1noc(n1)C(F)(F)F

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 504529   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone deacetylase 6 (Homo sapiens (Human))	BDBM504529 ((S)-1-(2,5-Difluoro-4-(5-(trifluoromethyl)-1,2,4-o...) Show SMILES Cc1noc(n1)[C@@H]1CCC(=O)N1c1cc(F)c(cc1F)-c1noc(n1)C(F)(F)F |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description HDAC1 and 6 reagents: FLAG-tagged HDACs 1 and 6 were prepared in-house by protein expression in HEK293F cells followed by anti-FLAG affinity purifica...				Citation and Details BindingDB Entry DOI: 10.7270/Q2DN485Z
					More data for this Ligand-Target Pair
Histone deacetylase 8 (Homo sapiens (Human))	BDBM504529 ((S)-1-(2,5-Difluoro-4-(5-(trifluoromethyl)-1,2,4-o...) Show SMILES Cc1noc(n1)[C@@H]1CCC(=O)N1c1cc(F)c(cc1F)-c1noc(n1)C(F)(F)F |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description HDAC8 reagents: HDAC8 was purchased from Enzo Life Sciences [catalog #BML-SE145]. Assays were performed with buffer containing 20 mM HEPES, pH 8.0 [B...				Citation and Details BindingDB Entry DOI: 10.7270/Q2DN485Z
					More data for this Ligand-Target Pair
Histone deacetylase 5 (Homo sapiens (Human))	BDBM504529 ((S)-1-(2,5-Difluoro-4-(5-(trifluoromethyl)-1,2,4-o...) Show SMILES Cc1noc(n1)[C@@H]1CCC(=O)N1c1cc(F)c(cc1F)-c1noc(n1)C(F)(F)F |r| Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description HDAC5 reagents: N-terminal GST tagged HDAC5 was purchased from BPS Bioscience [catalog #50045]. Assays were performed with buffer containing 20 mM HE...				Citation and Details BindingDB Entry DOI: 10.7270/Q2DN485Z
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Homo sapiens (Human))	BDBM504529 ((S)-1-(2,5-Difluoro-4-(5-(trifluoromethyl)-1,2,4-o...) Show SMILES Cc1noc(n1)[C@@H]1CCC(=O)N1c1cc(F)c(cc1F)-c1noc(n1)C(F)(F)F |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description HDAC1 and 6 reagents: FLAG-tagged HDACs 1 and 6 were prepared in-house by protein expression in HEK293F cells followed by anti-FLAG affinity purifica...				Citation and Details BindingDB Entry DOI: 10.7270/Q2DN485Z
					More data for this Ligand-Target Pair