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SMILES: Oc1ccc(cc1-c1nc(NCc2cccnc2)c2ccccc2n1)C#N

InChI Key: InChIKey=BPTUCHARDQHTEK-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50453889   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50453889 (CHEMBL4207984) Show SMILES Oc1ccc(cc1-c1nc(NCc2cccnc2)c2ccccc2n1)C#N Show InChI InChI=1S/C21H15N5O/c22-11-14-7-8-19(27)17(10-14)21-25-18-6-2-1-5-16(18)20(26-21)24-13-15-4-3-9-23-12-15/h1-10,12,27H,13H2,(H,24,25,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Wenzhou Medical University Curated by ChEMBL					Assay Description Inhibition of recombinant human EGFR d746-750/T790M/C797S mutant using poly-Glu-Tyr (4:1) as substrate after 2 hrs in presence of [gamma-33P]-ATP by ...				J Med Chem 61: 4290-4300 (2018) Article DOI: 10.1021/acs.jmedchem.7b01310 BindingDB Entry DOI: 10.7270/Q2VQ358D
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50453889 (CHEMBL4207984) Show SMILES Oc1ccc(cc1-c1nc(NCc2cccnc2)c2ccccc2n1)C#N Show InChI InChI=1S/C21H15N5O/c22-11-14-7-8-19(27)17(10-14)21-25-18-6-2-1-5-16(18)20(26-21)24-13-15-4-3-9-23-12-15/h1-10,12,27H,13H2,(H,24,25,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wenzhou Medical University Curated by ChEMBL					Assay Description Inhibition of wild type recombinant N-terminal GST-tagged human EGFR catalytic domain expressed in Sf9 insect cells using poly-Glu-Tyr (4:1) as subst...				J Med Chem 61: 4290-4300 (2018) Article DOI: 10.1021/acs.jmedchem.7b01310 BindingDB Entry DOI: 10.7270/Q2VQ358D
					More data for this Ligand-Target Pair