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SMILES: Cc1ccc(NC(=O)N2CCN(CC2)C(=O)c2cc(nc3ccccc23)-c2ccccc2)cc1

InChI Key: InChIKey=ROJMUWXKQNXYPK-UHFFFAOYSA-N

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50454353   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM50454353
PNG
(CHEMBL4216815)
Show SMILES Cc1ccc(NC(=O)N2CCN(CC2)C(=O)c2cc(nc3ccccc23)-c2ccccc2)cc1
Show InChI InChI=1S/C28H26N4O2/c1-20-11-13-22(14-12-20)29-28(34)32-17-15-31(16-18-32)27(33)24-19-26(21-7-3-2-4-8-21)30-25-10-6-5-9-23(24)25/h2-14,19H,15-18H2,1H3,(H,29,34)
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n/an/a 44n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced intracellular calcium level preincubated for 2.5 mins followed by caps...

Bioorg Med Chem 26: 845-854 (2018)


Article DOI: 10.1016/j.bmc.2017.12.048
BindingDB Entry DOI: 10.7270/Q27S7RDV
More data for this
Ligand-Target Pair