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SMILES: CC(C)CN(CC(C)C)c1ccc(cc1NC(=O)Nc1ccc(C)cc1)-c1ccccc1NS(C)(=O)=O

InChI Key: InChIKey=SXRHMNZWXLPWRM-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50454801   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (Human))		BDBM50454801
PNG
(CHEMBL4206646)
Show SMILES CC(C)CN(CC(C)C)c1ccc(cc1NC(=O)Nc1ccc(C)cc1)-c1ccccc1NS(C)(=O)=O
Show InChI InChI=1S/C29H38N4O3S/c1-20(2)18-33(19-21(3)4)28-16-13-23(25-9-7-8-10-26(25)32-37(6,35)36)17-27(28)31-29(34)30-24-14-11-22(5)12-15-24/h7-17,20-21,32H,18-19H2,1-6H3,(H2,30,31,34)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of IDO1 in IFN-gamma stimulated human HeLa cells assessed as inhibition of kynurenine production pre-incubated for 1 hr followed by IFN-ga...

Bioorg Med Chem Lett 28: 732-736 (2018)


Article DOI: 10.1016/j.bmcl.2018.01.010
BindingDB Entry DOI: 10.7270/Q28K7CP4
More data for this
Ligand-Target Pair