BindingDB PrimarySearch

BDBM50456444 CHEMBL3734823

SMILES: CC1=NN(C(=O)\C1=C\c1ccc(o1)-c1cc(C)c(C)cc1[N+]([O-])=O)c1ccc(cc1)C(O)=O

InChI Key: InChIKey=HEKJYZZSCQBJGB-XDHOZWIPSA-N

Data: 1 KI 8 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50456444
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
HIF1A/p300/CREB-binding protein (Homo sapiens (Human))	BDBM50456444 (CHEMBL3734823) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kyoto University Curated by ChEMBL					Assay Description Inhibition of VMA intein chitin binding domain-fused p300 HAT domain (1287 to 1652 residues) (unknown origin) expressed in Escherichia coli BL21(RIL)...				Eur J Med Chem 138: 320-327 (2017) Article DOI: 10.1016/j.ejmech.2017.06.037 BindingDB Entry DOI: 10.7270/Q2ZW1PHN
Kyoto University Curated by ChEMBL					More data for this Ligand-Target Pair
HIF1A/p300/CREB-binding protein (Homo sapiens (Human))	BDBM50456444 (CHEMBL3734823) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of P300 (unknown origin)				Bioorg Med Chem 26: 5397-5407 (2018) Article DOI: 10.1016/j.bmc.2018.07.048 BindingDB Entry DOI: 10.7270/Q2ZW1PM0
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Histone acetyltransferase KAT8 (Homo sapiens (Human))	BDBM50456444 (CHEMBL3734823) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	>6.31E+11	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibition of recombinant N-terminal His6-tagged KAT8 (unknown origin) expressed in Escherichia Coli BL21 DE3 cells assessed as reduction of Co A lev...				Eur J Med Chem 105: 289-96 (2015) Article DOI: 10.1016/j.ejmech.2015.10.016 BindingDB Entry DOI: 10.7270/Q2TT4TXW
University of Groningen Curated by ChEMBL					More data for this Ligand-Target Pair
HIF1A/p300/CREB-binding protein (Homo sapiens (Human))	BDBM50456444 (CHEMBL3734823) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of P300 (unknown origin) (1287 to 1652 residues) expressed in Escherichia coli BL21(RIL)-DE3 cells using [12C]-acetyl-CoA/[14C]-acetyl-CoA...				Eur J Med Chem 178: 259-286 (2019) Article DOI: 10.1016/j.ejmech.2019.05.078
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
HIF1A/p300/CREB-binding protein (Homo sapiens (Human))	BDBM50456444 (CHEMBL3734823) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.80	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of P300 BHC domain (unknown origin)				Eur J Med Chem 178: 259-286 (2019) Article DOI: 10.1016/j.ejmech.2019.05.078
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
CREB-binding protein (Homo sapiens (Human))	BDBM50456444 (CHEMBL3734823) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of CBP BHC domain (unknown origin)				Eur J Med Chem 178: 259-286 (2019) Article DOI: 10.1016/j.ejmech.2019.05.078
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
HIF1A/p300/CREB-binding protein (Homo sapiens (Human))	BDBM50456444 (CHEMBL3734823) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Noncompetitive inhibition of P300 (1287 to 1652 residues) VMA intein chitin binding domain (unknown origin) expressed in Escherichia coli BL21(RIL)-D...				Eur J Med Chem 178: 259-286 (2019) Article DOI: 10.1016/j.ejmech.2019.05.078
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
HIF1A/p300/CREB-binding protein (Homo sapiens (Human))	BDBM50456444 (CHEMBL3734823) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kyoto University Curated by ChEMBL					Assay Description Inhibition of p300 (unknown origin) using H3 peptide and acetyl-coA as substrate by fluorometric assay				Eur J Med Chem 138: 320-327 (2017) Article DOI: 10.1016/j.ejmech.2017.06.037 BindingDB Entry DOI: 10.7270/Q2ZW1PHN
Kyoto University Curated by ChEMBL					More data for this Ligand-Target Pair
HIF1A/p300/CREB-binding protein (Homo sapiens (Human))	BDBM50456444 (CHEMBL3734823) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibition of human recombinant Histone acetyltransferase p300 catalytic domain (1284-1672 residues) using [3H]Acetyl-CoA and histone H3 substrate at...				Eur J Med Chem 105: 289-96 (2015) Article DOI: 10.1016/j.ejmech.2015.10.016 BindingDB Entry DOI: 10.7270/Q2TT4TXW
University of Groningen Curated by ChEMBL					More data for this Ligand-Target Pair