null

SMILES: CC(C)[C@H](NC(=O)C(C)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1cc(F)c(=O)n(C)c1)c1ccccc1

InChI Key: InChIKey=CFBUFBFJMBWHPM-BJKOFHAPSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50457412   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50457412 (CHEMBL4209216) Show SMILES CC(C)[C@H](NC(=O)C(C)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1cc(F)c(=O)n(C)c1)c1ccccc1 |r| Show InChI InChI=1S/C27H27F3N4O3/c1-16(2)23(32-26(36)27(3,29)30)24(17-8-6-5-7-9-17)37-20-10-11-22-18(12-20)14-31-34(22)19-13-21(28)25(35)33(4)15-19/h5-16,23-24H,1-4H3,(H,32,36)/t23-,24+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.60	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Transrepression activity at glucocorticoid receptor (unknown origin) expressed in human ChaGoK1 cells assessed as inhibition of PMA-stimulated gene e...				J Med Chem 61: 1785-1799 (2018) Article DOI: 10.1021/acs.jmedchem.7b01690 BindingDB Entry DOI: 10.7270/Q2XK8J5R
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50457412 (CHEMBL4209216) Show SMILES CC(C)[C@H](NC(=O)C(C)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1cc(F)c(=O)n(C)c1)c1ccccc1 |r| Show InChI InChI=1S/C27H27F3N4O3/c1-16(2)23(32-26(36)27(3,29)30)24(17-8-6-5-7-9-17)37-20-10-11-22-18(12-20)14-31-34(22)19-13-21(28)25(35)33(4)15-19/h5-16,23-24H,1-4H3,(H,32,36)/t23-,24+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	301	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at glucocorticoid receptor (unknown origin) expressed in human ChaGoK1 cells assessed as inhibition of dexamethasone induced tran...				J Med Chem 61: 1785-1799 (2018) Article DOI: 10.1021/acs.jmedchem.7b01690 BindingDB Entry DOI: 10.7270/Q2XK8J5R
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50457412 (CHEMBL4209216) Show SMILES CC(C)[C@H](NC(=O)C(C)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1cc(F)c(=O)n(C)c1)c1ccccc1 |r| Show InChI InChI=1S/C27H27F3N4O3/c1-16(2)23(32-26(36)27(3,29)30)24(17-8-6-5-7-9-17)37-20-10-11-22-18(12-20)14-31-34(22)19-13-21(28)25(35)33(4)15-19/h5-16,23-24H,1-4H3,(H,32,36)/t23-,24+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	<3.20	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Displacement of fluormone RED from human full length glucocorticoid receptor after 4 hrs by fluorescence polarization assay				J Med Chem 61: 1785-1799 (2018) Article DOI: 10.1021/acs.jmedchem.7b01690 BindingDB Entry DOI: 10.7270/Q2XK8J5R
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50457412 (CHEMBL4209216) Show SMILES CC(C)[C@H](NC(=O)C(C)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1cc(F)c(=O)n(C)c1)c1ccccc1 |r| Show InChI InChI=1S/C27H27F3N4O3/c1-16(2)23(32-26(36)27(3,29)30)24(17-8-6-5-7-9-17)37-20-10-11-22-18(12-20)14-31-34(22)19-13-21(28)25(35)33(4)15-19/h5-16,23-24H,1-4H3,(H,32,36)/t23-,24+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	18	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Transactivation activity at glucocorticoid receptor (unknown origin) expressed in human ChaGoK1 cells incubated for 24 hrs by beta-galactosidase repo...				J Med Chem 61: 1785-1799 (2018) Article DOI: 10.1021/acs.jmedchem.7b01690 BindingDB Entry DOI: 10.7270/Q2XK8J5R
					More data for this Ligand-Target Pair