BDBM50458751 CHEMBL4204166

SMILES: Nc1cc(c(cn1)-c1cc(nc(n1)N1CCOCC1)C1(CC1)S(=O)(=O)c1cccc(F)c1)C(F)(F)F

InChI Key: InChIKey=LESWEGHJBSSCQS-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50458751   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
p110α/p85α (Homo sapiens (Human))	BDBM50458751 (CHEMBL4204166) Show SMILES Nc1cc(c(cn1)-c1cc(nc(n1)N1CCOCC1)C1(CC1)S(=O)(=O)c1cccc(F)c1)C(F)(F)F Show InChI InChI=1S/C23H21F4N5O3S/c24-14-2-1-3-15(10-14)36(33,34)22(4-5-22)19-12-18(30-21(31-19)32-6-8-35-9-7-32)16-13-29-20(28)11-17(16)23(25,26)27/h1-3,10-13H,4-9H2,(H2,28,29)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Shanghai Haiyan Pharmaceutical Technology Co. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant human full length N-terminal His-tagged p110alpha/p85alpha expressed in baculovirus expression system using PIP2 as substra...				ACS Med Chem Lett 9: 719-724 (2018) Article DOI: 10.1021/acsmedchemlett.8b00167 BindingDB Entry DOI: 10.7270/Q21V5HK8
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