null
SMILES: [H][C@]12CCc3c(Cc4ccc(F)cc4)ccnc3N1CCNC2
InChI Key: InChIKey=PUZQIEAXLJCDIM-MRXNPFEDSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
5-hydroxytryptamine receptor 2C (Homo sapiens (Human)) | BDBM50459710 (CHEMBL4212834 | US10836764, Compound 128) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1.65 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals, Inc. US Patent | Assay Description Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin... | US Patent US10836764 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2A (Homo sapiens (Human)) | BDBM50459710 (CHEMBL4212834 | US10836764, Compound 128) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 2.15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals, Inc. US Patent | Assay Description Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin... | US Patent US10836764 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2B (Homo sapiens (Human)) | BDBM50459710 (CHEMBL4212834 | US10836764, Compound 128) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 49 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals, Inc. US Patent | Assay Description Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin... | US Patent US10836764 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2B (Homo sapiens (Human)) | BDBM50459710 (CHEMBL4212834 | US10836764, Compound 128) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 307 | n/a | n/a | n/a | n/a |
Usona Institute Curated by ChEMBL | Assay Description Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulati... | ACS Med Chem Lett 9: 864-865 (2018) Article DOI: 10.1021/acsmedchemlett.8b00328 BindingDB Entry DOI: 10.7270/Q2XS5Z0D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2C (Homo sapiens (Human)) | BDBM50459710 (CHEMBL4212834 | US10836764, Compound 128) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 7.5 | n/a | n/a | n/a | n/a |
Usona Institute Curated by ChEMBL | Assay Description Agonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulati... | ACS Med Chem Lett 9: 864-865 (2018) Article DOI: 10.1021/acsmedchemlett.8b00328 BindingDB Entry DOI: 10.7270/Q2XS5Z0D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2A (Homo sapiens (Human)) | BDBM50459710 (CHEMBL4212834 | US10836764, Compound 128) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 100 | n/a | n/a | n/a | n/a |
Usona Institute Curated by ChEMBL | Assay Description Agonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulati... | ACS Med Chem Lett 9: 864-865 (2018) Article DOI: 10.1021/acsmedchemlett.8b00328 BindingDB Entry DOI: 10.7270/Q2XS5Z0D | |||||||||||
More data for this Ligand-Target Pair |