Found 4 hits for monomerid = 50460340 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50460340
(CHEMBL4228200)Show SMILES COc1ccc(-c2cn(Cc3nc4cccc(C)c4c(=O)n3-c3ccccc3C)nn2)c(C)c1 |(27.62,-21.79,;28.98,-21.07,;30.29,-21.88,;31.65,-21.16,;32.95,-21.98,;32.89,-23.52,;34.2,-24.34,;35.44,-23.43,;36.69,-24.32,;38.15,-23.84,;39.47,-24.63,;39.44,-26.17,;40.76,-26.97,;40.73,-28.51,;42.05,-29.3,;43.4,-28.56,;43.43,-27.02,;44.77,-26.28,;42.11,-26.22,;42.14,-24.69,;43.49,-23.94,;40.82,-23.89,;40.8,-22.35,;42.13,-21.56,;42.11,-20.02,;40.76,-19.27,;39.44,-20.06,;39.46,-21.6,;38.13,-22.38,;36.23,-25.79,;34.69,-25.8,;31.53,-24.24,;31.48,-25.78,;30.23,-23.42,)| Show InChI InChI=1S/C27H25N5O2/c1-17-8-5-6-11-24(17)32-25(28-22-10-7-9-18(2)26(22)27(32)33)16-31-15-23(29-30-31)21-13-12-20(34-4)14-19(21)3/h5-15H,16H2,1-4H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
India Academy of Scientific & Innovative Research (AcSIR)
Curated by ChEMBL
| Assay Description
Inhibition of PI3K-gamma (unknown origin) by cell free biochemical assay |
Bioorg Med Chem Lett 28: 1005-1010 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.032
BindingDB Entry DOI: 10.7270/Q29S1TN5 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50460340
(CHEMBL4228200)Show SMILES COc1ccc(-c2cn(Cc3nc4cccc(C)c4c(=O)n3-c3ccccc3C)nn2)c(C)c1 |(27.62,-21.79,;28.98,-21.07,;30.29,-21.88,;31.65,-21.16,;32.95,-21.98,;32.89,-23.52,;34.2,-24.34,;35.44,-23.43,;36.69,-24.32,;38.15,-23.84,;39.47,-24.63,;39.44,-26.17,;40.76,-26.97,;40.73,-28.51,;42.05,-29.3,;43.4,-28.56,;43.43,-27.02,;44.77,-26.28,;42.11,-26.22,;42.14,-24.69,;43.49,-23.94,;40.82,-23.89,;40.8,-22.35,;42.13,-21.56,;42.11,-20.02,;40.76,-19.27,;39.44,-20.06,;39.46,-21.6,;38.13,-22.38,;36.23,-25.79,;34.69,-25.8,;31.53,-24.24,;31.48,-25.78,;30.23,-23.42,)| Show InChI InChI=1S/C27H25N5O2/c1-17-8-5-6-11-24(17)32-25(28-22-10-7-9-18(2)26(22)27(32)33)16-31-15-23(29-30-31)21-13-12-20(34-4)14-19(21)3/h5-15H,16H2,1-4H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
India Academy of Scientific & Innovative Research (AcSIR)
Curated by ChEMBL
| Assay Description
Inhibition of PI3K-delta (unknown origin) by cell free biochemical assay |
Bioorg Med Chem Lett 28: 1005-1010 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.032
BindingDB Entry DOI: 10.7270/Q29S1TN5 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50460340
(CHEMBL4228200)Show SMILES COc1ccc(-c2cn(Cc3nc4cccc(C)c4c(=O)n3-c3ccccc3C)nn2)c(C)c1 |(27.62,-21.79,;28.98,-21.07,;30.29,-21.88,;31.65,-21.16,;32.95,-21.98,;32.89,-23.52,;34.2,-24.34,;35.44,-23.43,;36.69,-24.32,;38.15,-23.84,;39.47,-24.63,;39.44,-26.17,;40.76,-26.97,;40.73,-28.51,;42.05,-29.3,;43.4,-28.56,;43.43,-27.02,;44.77,-26.28,;42.11,-26.22,;42.14,-24.69,;43.49,-23.94,;40.82,-23.89,;40.8,-22.35,;42.13,-21.56,;42.11,-20.02,;40.76,-19.27,;39.44,-20.06,;39.46,-21.6,;38.13,-22.38,;36.23,-25.79,;34.69,-25.8,;31.53,-24.24,;31.48,-25.78,;30.23,-23.42,)| Show InChI InChI=1S/C27H25N5O2/c1-17-8-5-6-11-24(17)32-25(28-22-10-7-9-18(2)26(22)27(32)33)16-31-15-23(29-30-31)21-13-12-20(34-4)14-19(21)3/h5-15H,16H2,1-4H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.55E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
India Academy of Scientific & Innovative Research (AcSIR)
Curated by ChEMBL
| Assay Description
Inhibition of PI3K-beta (unknown origin) by cell free biochemical assay |
Bioorg Med Chem Lett 28: 1005-1010 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.032
BindingDB Entry DOI: 10.7270/Q29S1TN5 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50460340
(CHEMBL4228200)Show SMILES COc1ccc(-c2cn(Cc3nc4cccc(C)c4c(=O)n3-c3ccccc3C)nn2)c(C)c1 |(27.62,-21.79,;28.98,-21.07,;30.29,-21.88,;31.65,-21.16,;32.95,-21.98,;32.89,-23.52,;34.2,-24.34,;35.44,-23.43,;36.69,-24.32,;38.15,-23.84,;39.47,-24.63,;39.44,-26.17,;40.76,-26.97,;40.73,-28.51,;42.05,-29.3,;43.4,-28.56,;43.43,-27.02,;44.77,-26.28,;42.11,-26.22,;42.14,-24.69,;43.49,-23.94,;40.82,-23.89,;40.8,-22.35,;42.13,-21.56,;42.11,-20.02,;40.76,-19.27,;39.44,-20.06,;39.46,-21.6,;38.13,-22.38,;36.23,-25.79,;34.69,-25.8,;31.53,-24.24,;31.48,-25.78,;30.23,-23.42,)| Show InChI InChI=1S/C27H25N5O2/c1-17-8-5-6-11-24(17)32-25(28-22-10-7-9-18(2)26(22)27(32)33)16-31-15-23(29-30-31)21-13-12-20(34-4)14-19(21)3/h5-15H,16H2,1-4H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.90E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
India Academy of Scientific & Innovative Research (AcSIR)
Curated by ChEMBL
| Assay Description
Inhibition of PI3K-alpha (unknown origin) by cell free biochemical assay |
Bioorg Med Chem Lett 28: 1005-1010 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.032
BindingDB Entry DOI: 10.7270/Q29S1TN5 |
More data for this
Ligand-Target Pair | |
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