null

SMILES: CN(C)C1CCN(CC1)c1ccc(Nc2ncc3nc(Sc4ccccc4)n(C4CCOCC4)c3n2)cc1

InChI Key: InChIKey=XPDCETIJRALGKS-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50461174   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50461174 (CHEMBL4226676) Show SMILES CN(C)C1CCN(CC1)c1ccc(Nc2ncc3nc(Sc4ccccc4)n(C4CCOCC4)c3n2)cc1 Show InChI InChI=1S/C29H35N7OS/c1-34(2)22-12-16-35(17-13-22)23-10-8-21(9-11-23)31-28-30-20-26-27(33-28)36(24-14-18-37-19-15-24)29(32-26)38-25-6-4-3-5-7-25/h3-11,20,22,24H,12-19H2,1-2H3,(H,30,31,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	331	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin) using poly (Glu, Tyr) as substrate after 40 mins by kinase-glo plus luminescence ...				Bioorg Med Chem 26: 2173-2185 (2018) Article DOI: 10.1016/j.bmc.2018.03.025 BindingDB Entry DOI: 10.7270/Q2H41V28
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50461174 (CHEMBL4226676) Show SMILES CN(C)C1CCN(CC1)c1ccc(Nc2ncc3nc(Sc4ccccc4)n(C4CCOCC4)c3n2)cc1 Show InChI InChI=1S/C29H35N7OS/c1-34(2)22-12-16-35(17-13-22)23-10-8-21(9-11-23)31-28-30-20-26-27(33-28)36(24-14-18-37-19-15-24)29(32-26)38-25-6-4-3-5-7-25/h3-11,20,22,24H,12-19H2,1-2H3,(H,30,31,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of wild type EGFR (unknown origin) using poly (Glu, Tyr) as substrate after 40 mins by kinase-glo plus luminescence assay				Bioorg Med Chem 26: 2173-2185 (2018) Article DOI: 10.1016/j.bmc.2018.03.025 BindingDB Entry DOI: 10.7270/Q2H41V28
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3 (Homo sapiens (Human))	BDBM50461174 (CHEMBL4226676) Show SMILES CN(C)C1CCN(CC1)c1ccc(Nc2ncc3nc(Sc4ccccc4)n(C4CCOCC4)c3n2)cc1 Show InChI InChI=1S/C29H35N7OS/c1-34(2)22-12-16-35(17-13-22)23-10-8-21(9-11-23)31-28-30-20-26-27(33-28)36(24-14-18-37-19-15-24)29(32-26)38-25-6-4-3-5-7-25/h3-11,20,22,24H,12-19H2,1-2H3,(H,30,31,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of EGFR L858R mutant (unknown origin) using poly (Glu, Tyr) as substrate after 40 mins by kinase-glo plus luminescence assay				Bioorg Med Chem 26: 2173-2185 (2018) Article DOI: 10.1016/j.bmc.2018.03.025 BindingDB Entry DOI: 10.7270/Q2H41V28
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50461174 (CHEMBL4226676) Show SMILES CN(C)C1CCN(CC1)c1ccc(Nc2ncc3nc(Sc4ccccc4)n(C4CCOCC4)c3n2)cc1 Show InChI InChI=1S/C29H35N7OS/c1-34(2)22-12-16-35(17-13-22)23-10-8-21(9-11-23)31-28-30-20-26-27(33-28)36(24-14-18-37-19-15-24)29(32-26)38-25-6-4-3-5-7-25/h3-11,20,22,24H,12-19H2,1-2H3,(H,30,31,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	104	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of EGFR L858R/T790M double mutant (unknown origin) using poly (Glu, Tyr) as substrate after 40 mins by kinase-glo plus luminescence assay				Bioorg Med Chem 26: 2173-2185 (2018) Article DOI: 10.1016/j.bmc.2018.03.025 BindingDB Entry DOI: 10.7270/Q2H41V28
					More data for this Ligand-Target Pair