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SMILES: CN1CCN(CC1)c1ccc(Nc2ncc3nc([S+]([O-])c4ccccc4)n(C4CCCC4)c3n2)cc1

InChI Key: InChIKey=QWFNKFQGVFUCAN-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50461177   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM50461177
PNG
(CHEMBL4225951)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3nc([S+]([O-])c4ccccc4)n(C4CCCC4)c3n2)cc1
Show InChI InChI=1S/C27H31N7OS/c1-32-15-17-33(18-16-32)21-13-11-20(12-14-21)29-26-28-19-24-25(31-26)34(22-7-5-6-8-22)27(30-24)36(35)23-9-3-2-4-10-23/h2-4,9-14,19,22H,5-8,15-18H2,1H3,(H,28,29,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 4.20n/an/an/an/an/an/a



Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of EGFR L858R mutant (unknown origin) using poly (Glu, Tyr) as substrate after 40 mins by kinase-glo plus luminescence assay

Bioorg Med Chem 26: 2173-2185 (2018)


Article DOI: 10.1016/j.bmc.2018.03.025
BindingDB Entry DOI: 10.7270/Q2H41V28
More data for this
Ligand-Target Pair