BDBM50461463 CHEMBL4225442
SMILES: CCCOc1c2CN(C(=O)c2c(OCCC)c2ccccc12)c1ccc(CC(O)=O)cc1
InChI Key: InChIKey=VBNVZRRAFYGCKK-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Prostaglandin E2 receptor (Homo sapiens (Human)) | BDBM50461463 (CHEMBL4225442) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | Article PubMed | 631 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK 293 (EBNA) cell membranes incubated for 60 mins by scintillation counting method | Bioorg Med Chem Lett 28: 1892-1896 (2018) Article DOI: 10.1016/j.bmcl.2018.03.091 BindingDB Entry DOI: 10.7270/Q21Z472W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin E2 receptor (Homo sapiens (Human)) | BDBM50461463 (CHEMBL4225442) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 126 | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Partial agonist activity at human EP4 receptor expressed in HEK293-AEQ17 cells assessed as cAMP accumulation by aequorin luminescence assay | Bioorg Med Chem Lett 28: 1892-1896 (2018) Article DOI: 10.1016/j.bmcl.2018.03.091 BindingDB Entry DOI: 10.7270/Q21Z472W | |||||||||||
More data for this Ligand-Target Pair |