BDBM50462315 CHEMBL4248225

SMILES: Oc1ccc(cc1)-c1nc(Cl)c(-c2ccccc2)c(Oc2ccc(OCCN3CCCC3)cc2)n1

InChI Key: InChIKey=HWRKYJBCLUXFOY-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50462315   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50462315 (CHEMBL4248225) Show SMILES Oc1ccc(cc1)-c1nc(Cl)c(-c2ccccc2)c(Oc2ccc(OCCN3CCCC3)cc2)n1 Show InChI InChI=1S/C28H26ClN3O3/c29-26-25(20-6-2-1-3-7-20)28(31-27(30-26)21-8-10-22(33)11-9-21)35-24-14-12-23(13-15-24)34-19-18-32-16-4-5-17-32/h1-3,6-15,33H,4-5,16-19H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	85	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of VEGFR2 (unknown origin) using TK substrate after 1 hr by HTRF assay				Eur J Med Chem 150: 783-795 (2018) Article DOI: 10.1016/j.ejmech.2018.03.018 BindingDB Entry DOI: 10.7270/Q2959M6P
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM50462315 (CHEMBL4248225) Show SMILES Oc1ccc(cc1)-c1nc(Cl)c(-c2ccccc2)c(Oc2ccc(OCCN3CCCC3)cc2)n1 Show InChI InChI=1S/C28H26ClN3O3/c29-26-25(20-6-2-1-3-7-20)28(31-27(30-26)21-8-10-22(33)11-9-21)35-24-14-12-23(13-15-24)34-19-18-32-16-4-5-17-32/h1-3,6-15,33H,4-5,16-19H2	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.64E+3	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Displacement of Fluormone ES2 Green from full length human ER-alpha expressed in insect cells after 2 hrs by fluorescence polarization assay				Eur J Med Chem 150: 783-795 (2018) Article DOI: 10.1016/j.ejmech.2018.03.018 BindingDB Entry DOI: 10.7270/Q2959M6P
					More data for this Ligand-Target Pair