BDBM50462340 CHEMBL4247640

SMILES: CC(C)Cc1ccc(cc1)C(C)c1nc2cc(ccc2n1Cc1ccccc1Cl)-c1nnco1

InChI Key: InChIKey=KQZCTTDQKPXYME-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50462340   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-lipoxygenase/FLAP (Homo sapiens (Human))	BDBM50462340 (CHEMBL4247640) Show SMILES CC(C)Cc1ccc(cc1)C(C)c1nc2cc(ccc2n1Cc1ccccc1Cl)-c1nnco1 Show InChI InChI=1S/C28H27ClN4O/c1-18(2)14-20-8-10-21(11-9-20)19(3)27-31-25-15-22(28-32-30-17-34-28)12-13-26(25)33(27)16-23-6-4-5-7-24(23)29/h4-13,15,17-19H,14,16H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
Gazi University Curated by ChEMBL					Assay Description Inhibition of FLAP in A23187-stimulated human neutrophils assessed as reduction in 5-LO product formation preincubated for 15 mins followed by A23187...				Eur J Med Chem 150: 876-899 (2018) Article DOI: 10.1016/j.ejmech.2018.03.045 BindingDB Entry DOI: 10.7270/Q25D8VHD
					More data for this Ligand-Target Pair