BDBM50462621 CHEMBL1813256::MLN-9708
SMILES: CC(C)C[C@H](NC(=O)CNC(=O)c1cc(Cl)ccc1Cl)B1OC(=O)CC(CC(O)=O)(O1)C(O)=O
InChI Key: InChIKey=YTXSYWAKVMZICI-PVCZSOGJSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Proteasome Macropain subunit (Homo sapiens (Human)) | BDBM50462621 (CHEMBL1813256 | MLN-9708) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 7.95E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Nanjing Forestry University Curated by ChEMBL | Assay Description Inhibition of trypsin-like activity of human 20S proteasome | Bioorg Med Chem 26: 3975-3981 (2018) Article DOI: 10.1016/j.bmc.2018.06.020 BindingDB Entry DOI: 10.7270/Q2Q81GQG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proteasome subunit beta type-1/beta type-5 (Homo sapiens (Human)) | BDBM50462621 (CHEMBL1813256 | MLN-9708) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 8.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Nanjing Forestry University Curated by ChEMBL | Assay Description Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate incubated for 10 mins followed by substra... | Bioorg Med Chem 26: 3975-3981 (2018) Article DOI: 10.1016/j.bmc.2018.06.020 BindingDB Entry DOI: 10.7270/Q2Q81GQG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent Clp protease proteolytic subunit (Staphylococcus aureus (strain NCTC 8325)) | BDBM50462621 (CHEMBL1813256 | MLN-9708) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 1.99E+4 | n/a | n/a | n/a | n/a |
Sichuan University Curated by ChEMBL | Assay Description Binding affinity to N-terminal His6-sumo-tagged full length Staphylococcus aureus ClpP expressed in Escherichia coli BL2 (DE3) assessed as shifting o... | J Med Chem 63: 3104-3119 (2020) Article DOI: 10.1021/acs.jmedchem.9b01746 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent Clp protease proteolytic subunit (Staphylococcus aureus (strain NCTC 8325)) | BDBM50462621 (CHEMBL1813256 | MLN-9708) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 7.30E+3 | n/a | n/a | n/a | n/a | n/a |
Sichuan University Curated by ChEMBL | Assay Description Binding affinity to N-terminal His6-sumo-tagged full length Staphylococcus aureus ClpP expressed in Escherichia coli BL2 (DE3) by ITC analysis | J Med Chem 63: 3104-3119 (2020) Article DOI: 10.1021/acs.jmedchem.9b01746 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proteasome component C5 (Homo sapiens (Human)) | BDBM50462621 (CHEMBL1813256 | MLN-9708) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Nanjing Forestry University Curated by ChEMBL | Assay Description Inhibition of caspase-like activity of human 20S proteasome | Bioorg Med Chem 26: 3975-3981 (2018) Article DOI: 10.1016/j.bmc.2018.06.020 BindingDB Entry DOI: 10.7270/Q2Q81GQG | |||||||||||
More data for this Ligand-Target Pair |