BDBM50465014 CHEMBL4282274

SMILES: COc1ccc(cc1OC)-c1nc(ncc1C(=O)Nc1ccncc1)C(F)(F)F

InChI Key: InChIKey=WYPQDUGRCRAKKH-UHFFFAOYSA-N

Data: 8 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50465014   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphodiesterase 4 and 5 (PDE4 and PDE5) (Homo sapiens (Human))	BDBM50465014 (CHEMBL4282274) Show SMILES COc1ccc(cc1OC)-c1nc(ncc1C(=O)Nc1ccncc1)C(F)(F)F Show InChI InChI=1S/C19H15F3N4O3/c1-28-14-4-3-11(9-15(14)29-2)16-13(10-24-18(26-16)19(20,21)22)17(27)25-12-5-7-23-8-6-12/h3-10H,1-2H3,(H,23,25,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	98	n/a	n/a	n/a	n/a	n/a	n/a
Seoul National University Curated by ChEMBL					Assay Description Inhibition of recombinant full length human N-terminal GST-tagged PDE4A1 expressed in baculovirus infected Sf9 cells using cAMP as substrate after 1 ...				Eur J Med Chem 145: 673-690 (2018) Article DOI: 10.1016/j.ejmech.2017.12.069 BindingDB Entry DOI: 10.7270/Q21R6T6D
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B (Homo sapiens (Human))	BDBM50465014 (CHEMBL4282274) Show SMILES COc1ccc(cc1OC)-c1nc(ncc1C(=O)Nc1ccncc1)C(F)(F)F Show InChI InChI=1S/C19H15F3N4O3/c1-28-14-4-3-11(9-15(14)29-2)16-13(10-24-18(26-16)19(20,21)22)17(27)25-12-5-7-23-8-6-12/h3-10H,1-2H3,(H,23,25,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	169	n/a	n/a	n/a	n/a	n/a	n/a
Seoul National University Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal GST-tagged PDE3B (592-end residues) expressed in baculovirus infected Sf9 cells using cAMP as substrate af...				Eur J Med Chem 145: 673-690 (2018) Article DOI: 10.1016/j.ejmech.2017.12.069 BindingDB Entry DOI: 10.7270/Q21R6T6D
					More data for this Ligand-Target Pair
Phosphodiesterase 11A (Homo sapiens (Human))	BDBM50465014 (CHEMBL4282274) Show SMILES COc1ccc(cc1OC)-c1nc(ncc1C(=O)Nc1ccncc1)C(F)(F)F Show InChI InChI=1S/C19H15F3N4O3/c1-28-14-4-3-11(9-15(14)29-2)16-13(10-24-18(26-16)19(20,21)22)17(27)25-12-5-7-23-8-6-12/h3-10H,1-2H3,(H,23,25,27)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
Seoul National University Curated by ChEMBL					Assay Description Inhibition of PDE11A (unknown origin) using cAMP as substrate after 1 hr by LANCE TR-FRET assay				Eur J Med Chem 145: 673-690 (2018) Article DOI: 10.1016/j.ejmech.2017.12.069 BindingDB Entry DOI: 10.7270/Q21R6T6D
					More data for this Ligand-Target Pair
3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50465014 (CHEMBL4282274) Show SMILES COc1ccc(cc1OC)-c1nc(ncc1C(=O)Nc1ccncc1)C(F)(F)F Show InChI InChI=1S/C19H15F3N4O3/c1-28-14-4-3-11(9-15(14)29-2)16-13(10-24-18(26-16)19(20,21)22)17(27)25-12-5-7-23-8-6-12/h3-10H,1-2H3,(H,23,25,27)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Seoul National University Curated by ChEMBL					Assay Description Inhibition of recombinant full length human N-terminal GST-tagged PDE4B1 expressed in baculovirus infected Sf9 cells using cAMP as substrate after 1 ...				Eur J Med Chem 145: 673-690 (2018) Article DOI: 10.1016/j.ejmech.2017.12.069 BindingDB Entry DOI: 10.7270/Q21R6T6D
					More data for this Ligand-Target Pair
3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50465014 (CHEMBL4282274) Show SMILES COc1ccc(cc1OC)-c1nc(ncc1C(=O)Nc1ccncc1)C(F)(F)F Show InChI InChI=1S/C19H15F3N4O3/c1-28-14-4-3-11(9-15(14)29-2)16-13(10-24-18(26-16)19(20,21)22)17(27)25-12-5-7-23-8-6-12/h3-10H,1-2H3,(H,23,25,27)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Seoul National University Curated by ChEMBL					Assay Description Inhibition of recombinant human full length N-terminal GST-tagged PDE4B1 expressed in baculovirus infected Sf9 cells using cAMP as substrate after 1 ...				Eur J Med Chem 145: 673-690 (2018) Article DOI: 10.1016/j.ejmech.2017.12.069 BindingDB Entry DOI: 10.7270/Q21R6T6D
					More data for this Ligand-Target Pair
3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50465014 (CHEMBL4282274) Show SMILES COc1ccc(cc1OC)-c1nc(ncc1C(=O)Nc1ccncc1)C(F)(F)F Show InChI InChI=1S/C19H15F3N4O3/c1-28-14-4-3-11(9-15(14)29-2)16-13(10-24-18(26-16)19(20,21)22)17(27)25-12-5-7-23-8-6-12/h3-10H,1-2H3,(H,23,25,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	57	n/a	n/a	n/a	n/a	n/a	n/a
Seoul National University Curated by ChEMBL					Assay Description Inhibition of recombinant human full length N-terminal GST-tagged PDE4C1 expressed in baculovirus infected Sf9 cells using cAMP as substrate after 1 ...				Eur J Med Chem 145: 673-690 (2018) Article DOI: 10.1016/j.ejmech.2017.12.069 BindingDB Entry DOI: 10.7270/Q21R6T6D
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50465014 (CHEMBL4282274) Show SMILES COc1ccc(cc1OC)-c1nc(ncc1C(=O)Nc1ccncc1)C(F)(F)F Show InChI InChI=1S/C19H15F3N4O3/c1-28-14-4-3-11(9-15(14)29-2)16-13(10-24-18(26-16)19(20,21)22)17(27)25-12-5-7-23-8-6-12/h3-10H,1-2H3,(H,23,25,27)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	108	n/a	n/a	n/a	n/a	n/a	n/a
Seoul National University Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal GST-tagged PDE4D7 (2 to 748 residues) expressed in baculovirus infected Sf9 cells using cAMP as substrate ...				Eur J Med Chem 145: 673-690 (2018) Article DOI: 10.1016/j.ejmech.2017.12.069 BindingDB Entry DOI: 10.7270/Q21R6T6D
					More data for this Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5) (Homo sapiens (Human))	BDBM50465014 (CHEMBL4282274) Show SMILES COc1ccc(cc1OC)-c1nc(ncc1C(=O)Nc1ccncc1)C(F)(F)F Show InChI InChI=1S/C19H15F3N4O3/c1-28-14-4-3-11(9-15(14)29-2)16-13(10-24-18(26-16)19(20,21)22)17(27)25-12-5-7-23-8-6-12/h3-10H,1-2H3,(H,23,25,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	152	n/a	n/a	n/a	n/a	n/a	n/a
Seoul National University Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal GST-tagged PDE4A4 (2 to 886 residues) expressed in baculovirus infected Sf9 cells using cAMP as substrate ...				Eur J Med Chem 145: 673-690 (2018) Article DOI: 10.1016/j.ejmech.2017.12.069 BindingDB Entry DOI: 10.7270/Q21R6T6D
					More data for this Ligand-Target Pair