BDBM50465912 CHEMBL4287623
SMILES: [#8]C1([#6]-[#6]-[#7](-[#6]-[#6]-[#6]\[#6]=[#6](/c2ccc(F)cc2)-c2ccc(F)cc2)-[#6]-[#6]1)c1ccc(Cl)c(c1)C(F)(F)F
InChI Key: InChIKey=GOFKTWKLJPDQCU-UHFFFAOYSA-N
Data: 12 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50465912 (CHEMBL4287623) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 317 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Texas Tech University Health Sciences Center Curated by ChEMBL | Assay Description Displacement of [3H]N-methylspiperone from human dopamine D2 receptor expressed in stable fibroblast cells by radioligand binding assay | Bioorg Med Chem Lett 28: 3652-3657 (2018) Article DOI: 10.1016/j.bmcl.2018.10.036 BindingDB Entry DOI: 10.7270/Q280558N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mu-type opioid receptor (Homo sapiens (Human)) | BDBM50465912 (CHEMBL4287623) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 328 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Texas Tech University Health Sciences Center Curated by ChEMBL | Assay Description Displacement of [3H]DAMGO from human MOR expressed in HEK cells by radioligand binding assay | Bioorg Med Chem Lett 28: 3652-3657 (2018) Article DOI: 10.1016/j.bmcl.2018.10.036 BindingDB Entry DOI: 10.7270/Q280558N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H2 receptor (Homo sapiens (Human)) | BDBM50465912 (CHEMBL4287623) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 526 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Texas Tech University Health Sciences Center Curated by ChEMBL | Assay Description Displacement of [3H]Cimetidine from human H2 receptor expressed in HEK cells by radioligand binding assay | Bioorg Med Chem Lett 28: 3652-3657 (2018) Article DOI: 10.1016/j.bmcl.2018.10.036 BindingDB Entry DOI: 10.7270/Q280558N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(3) dopamine receptor (Homo sapiens (Human)) | BDBM50465912 (CHEMBL4287623) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 552 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Texas Tech University Health Sciences Center Curated by ChEMBL | Assay Description Displacement of [3H]N-methylspiperone from human dopamine D3 receptor expressed in HEK293T cells by radioligand binding assay | Bioorg Med Chem Lett 28: 3652-3657 (2018) Article DOI: 10.1016/j.bmcl.2018.10.036 BindingDB Entry DOI: 10.7270/Q280558N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H1 receptor (Homo sapiens (Human)) | BDBM50465912 (CHEMBL4287623) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 718 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Texas Tech University Health Sciences Center Curated by ChEMBL | Assay Description Displacement of [3H]Pyrilamine from human H1 receptor expressed in HEK cells by radioligand binding assay | Bioorg Med Chem Lett 28: 3652-3657 (2018) Article DOI: 10.1016/j.bmcl.2018.10.036 BindingDB Entry DOI: 10.7270/Q280558N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Homo sapiens (Human)) | BDBM50465912 (CHEMBL4287623) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 1.02E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Texas Tech University Health Sciences Center Curated by ChEMBL | Assay Description Displacement of [3H]U69593 from KOR (unknown origin) expressed in HEK cells by radioligand binding assay | Bioorg Med Chem Lett 28: 3652-3657 (2018) Article DOI: 10.1016/j.bmcl.2018.10.036 BindingDB Entry DOI: 10.7270/Q280558N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2A (Homo sapiens (Human)) | BDBM50465912 (CHEMBL4287623) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 1.11E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Texas Tech University Health Sciences Center Curated by ChEMBL | Assay Description Displacement of [3H]Ketanserin from 5-HT2A receptor (unknown origin) by radioligand binding assay | Bioorg Med Chem Lett 28: 3652-3657 (2018) Article DOI: 10.1016/j.bmcl.2018.10.036 BindingDB Entry DOI: 10.7270/Q280558N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50465912 (CHEMBL4287623) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 1.36E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Texas Tech University Health Sciences Center Curated by ChEMBL | Assay Description Displacement of [3H]-Way100635 from human 5HT1A receptor expressed in stable CHO cell membranes by radioligand binding assay | Bioorg Med Chem Lett 28: 3652-3657 (2018) Article DOI: 10.1016/j.bmcl.2018.10.036 BindingDB Entry DOI: 10.7270/Q280558N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2C (Homo sapiens (Human)) | BDBM50465912 (CHEMBL4287623) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Texas Tech University Health Sciences Center Curated by ChEMBL | Assay Description Displacement of [3H]Mesulergine from human 5-HT2C receptor expressed in HEK293FlpIN cells by radioligand binding assay | Bioorg Med Chem Lett 28: 3652-3657 (2018) Article DOI: 10.1016/j.bmcl.2018.10.036 BindingDB Entry DOI: 10.7270/Q280558N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(4) dopamine receptor (Homo sapiens (Human)) | BDBM50465912 (CHEMBL4287623) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 1.64E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Texas Tech University Health Sciences Center Curated by ChEMBL | Assay Description Displacement of [3H]N-methylspiperone from human dopamine D4 receptor by radioligand binding assay | Bioorg Med Chem Lett 28: 3652-3657 (2018) Article DOI: 10.1016/j.bmcl.2018.10.036 BindingDB Entry DOI: 10.7270/Q280558N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2B (Homo sapiens (Human)) | BDBM50465912 (CHEMBL4287623) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Texas Tech University Health Sciences Center Curated by ChEMBL | Assay Description Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay | Bioorg Med Chem Lett 28: 3652-3657 (2018) Article DOI: 10.1016/j.bmcl.2018.10.036 BindingDB Entry DOI: 10.7270/Q280558N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 7 (Homo sapiens (Human)) | BDBM50465912 (CHEMBL4287623) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Texas Tech University Health Sciences Center Curated by ChEMBL | Assay Description Displacement of [3H]LSD from human 5-HT7A receptor expressed in HEK cells by radioligand binding assay | Bioorg Med Chem Lett 28: 3652-3657 (2018) Article DOI: 10.1016/j.bmcl.2018.10.036 BindingDB Entry DOI: 10.7270/Q280558N | |||||||||||
More data for this Ligand-Target Pair |