Found 20 hits for monomerid = 50466542 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM50466542
(CHEMBL4290445)Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N(C)[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O |r| Show InChI InChI=1S/C186H279N53O55/c1-16-94(10)147(191)175(286)219-118(30-19-20-64-187)180(291)238-70-26-36-136(238)173(284)215-115(56-61-143(253)254)152(263)210-97(13)178(289)237-69-25-35-135(237)171(282)206-86-141(250)211-114(55-60-142(251)252)156(267)230-130(83-146(259)260)160(271)209-96(12)151(262)233-133(88-241)181(292)239-71-27-37-137(239)174(285)216-117(58-63-145(257)258)157(268)214-116(57-62-144(255)256)158(269)220-121(73-91(4)5)162(273)228-128(81-139(189)248)167(278)213-111(31-21-65-201-183(192)193)154(265)223-124(76-100-40-48-106(244)49-41-100)165(276)224-123(75-99-38-46-105(243)47-39-99)159(270)208-95(11)150(261)232-132(87-240)170(281)222-120(72-90(2)3)161(272)212-112(32-22-66-202-184(194)195)155(266)227-127(80-104-85-200-89-207-104)166(277)225-125(77-101-42-50-107(245)51-43-101)164(275)221-122(74-92(6)7)163(274)229-129(82-140(190)249)168(279)226-126(79-103-84-205-110-29-18-17-28-109(103)110)169(280)234-148(93(8)9)176(287)235-149(98(14)242)177(288)217-113(33-23-67-203-185(196)197)153(264)218-119(54-59-138(188)247)179(290)236(15)134(34-24-68-204-186(198)199)172(283)231-131(182(293)294)78-102-44-52-108(246)53-45-102/h17-18,28-29,38-53,84-85,89-98,111-137,147-149,205,240-246H,16,19-27,30-37,54-83,86-88,187,191H2,1-15H3,(H2,188,247)(H2,189,248)(H2,190,249)(H,200,207)(H,206,282)(H,208,270)(H,209,271)(H,210,263)(H,211,250)(H,212,272)(H,213,278)(H,214,268)(H,215,284)(H,216,285)(H,217,288)(H,218,264)(H,219,286)(H,220,269)(H,221,275)(H,222,281)(H,223,265)(H,224,276)(H,225,277)(H,226,279)(H,227,266)(H,228,273)(H,229,274)(H,230,267)(H,231,283)(H,232,261)(H,233,262)(H,234,280)(H,235,287)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H,293,294)(H4,192,193,201)(H4,194,195,202)(H4,196,197,203)(H4,198,199,204)/t94-,95-,96-,97-,98+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,147-,148-,149-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| 0.630 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [125I]-PYY(1 to 36 residues) from human Y2R expressed in CHO cell membranes after 2 hrs by scintillation proximity assay |
J Med Chem 61: 10519-10530 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM50466542
(CHEMBL4290445)Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N(C)[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O |r| Show InChI InChI=1S/C186H279N53O55/c1-16-94(10)147(191)175(286)219-118(30-19-20-64-187)180(291)238-70-26-36-136(238)173(284)215-115(56-61-143(253)254)152(263)210-97(13)178(289)237-69-25-35-135(237)171(282)206-86-141(250)211-114(55-60-142(251)252)156(267)230-130(83-146(259)260)160(271)209-96(12)151(262)233-133(88-241)181(292)239-71-27-37-137(239)174(285)216-117(58-63-145(257)258)157(268)214-116(57-62-144(255)256)158(269)220-121(73-91(4)5)162(273)228-128(81-139(189)248)167(278)213-111(31-21-65-201-183(192)193)154(265)223-124(76-100-40-48-106(244)49-41-100)165(276)224-123(75-99-38-46-105(243)47-39-99)159(270)208-95(11)150(261)232-132(87-240)170(281)222-120(72-90(2)3)161(272)212-112(32-22-66-202-184(194)195)155(266)227-127(80-104-85-200-89-207-104)166(277)225-125(77-101-42-50-107(245)51-43-101)164(275)221-122(74-92(6)7)163(274)229-129(82-140(190)249)168(279)226-126(79-103-84-205-110-29-18-17-28-109(103)110)169(280)234-148(93(8)9)176(287)235-149(98(14)242)177(288)217-113(33-23-67-203-185(196)197)153(264)218-119(54-59-138(188)247)179(290)236(15)134(34-24-68-204-186(198)199)172(283)231-131(182(293)294)78-102-44-52-108(246)53-45-102/h17-18,28-29,38-53,84-85,89-98,111-137,147-149,205,240-246H,16,19-27,30-37,54-83,86-88,187,191H2,1-15H3,(H2,188,247)(H2,189,248)(H2,190,249)(H,200,207)(H,206,282)(H,208,270)(H,209,271)(H,210,263)(H,211,250)(H,212,272)(H,213,278)(H,214,268)(H,215,284)(H,216,285)(H,217,288)(H,218,264)(H,219,286)(H,220,269)(H,221,275)(H,222,281)(H,223,265)(H,224,276)(H,225,277)(H,226,279)(H,227,266)(H,228,273)(H,229,274)(H,230,267)(H,231,283)(H,232,261)(H,233,262)(H,234,280)(H,235,287)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H,293,294)(H4,192,193,201)(H4,194,195,202)(H4,196,197,203)(H4,198,199,204)/t94-,95-,96-,97-,98+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,147-,148-,149-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 0.631 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [125I]-PYY(1 to 36 residues) from human Y2R expressed in CHO cell membranes after 2 hrs by scintillation proximity assay |
J Med Chem 61: 10519-10530 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50466542
(CHEMBL4290445)Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N(C)[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O |r| Show InChI InChI=1S/C186H279N53O55/c1-16-94(10)147(191)175(286)219-118(30-19-20-64-187)180(291)238-70-26-36-136(238)173(284)215-115(56-61-143(253)254)152(263)210-97(13)178(289)237-69-25-35-135(237)171(282)206-86-141(250)211-114(55-60-142(251)252)156(267)230-130(83-146(259)260)160(271)209-96(12)151(262)233-133(88-241)181(292)239-71-27-37-137(239)174(285)216-117(58-63-145(257)258)157(268)214-116(57-62-144(255)256)158(269)220-121(73-91(4)5)162(273)228-128(81-139(189)248)167(278)213-111(31-21-65-201-183(192)193)154(265)223-124(76-100-40-48-106(244)49-41-100)165(276)224-123(75-99-38-46-105(243)47-39-99)159(270)208-95(11)150(261)232-132(87-240)170(281)222-120(72-90(2)3)161(272)212-112(32-22-66-202-184(194)195)155(266)227-127(80-104-85-200-89-207-104)166(277)225-125(77-101-42-50-107(245)51-43-101)164(275)221-122(74-92(6)7)163(274)229-129(82-140(190)249)168(279)226-126(79-103-84-205-110-29-18-17-28-109(103)110)169(280)234-148(93(8)9)176(287)235-149(98(14)242)177(288)217-113(33-23-67-203-185(196)197)153(264)218-119(54-59-138(188)247)179(290)236(15)134(34-24-68-204-186(198)199)172(283)231-131(182(293)294)78-102-44-52-108(246)53-45-102/h17-18,28-29,38-53,84-85,89-98,111-137,147-149,205,240-246H,16,19-27,30-37,54-83,86-88,187,191H2,1-15H3,(H2,188,247)(H2,189,248)(H2,190,249)(H,200,207)(H,206,282)(H,208,270)(H,209,271)(H,210,263)(H,211,250)(H,212,272)(H,213,278)(H,214,268)(H,215,284)(H,216,285)(H,217,288)(H,218,264)(H,219,286)(H,220,269)(H,221,275)(H,222,281)(H,223,265)(H,224,276)(H,225,277)(H,226,279)(H,227,266)(H,228,273)(H,229,274)(H,230,267)(H,231,283)(H,232,261)(H,233,262)(H,234,280)(H,235,287)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H,293,294)(H4,192,193,201)(H4,194,195,202)(H4,196,197,203)(H4,198,199,204)/t94-,95-,96-,97-,98+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,147-,148-,149-/m0/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 398 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [125I]-PYY(1 to 36 residues) from human Y5R expressed in HEK293 cell membranes after 2 hrs by scintillation proximity assay |
J Med Chem 61: 10519-10530 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50466542
(CHEMBL4290445)Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N(C)[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O |r| Show InChI InChI=1S/C186H279N53O55/c1-16-94(10)147(191)175(286)219-118(30-19-20-64-187)180(291)238-70-26-36-136(238)173(284)215-115(56-61-143(253)254)152(263)210-97(13)178(289)237-69-25-35-135(237)171(282)206-86-141(250)211-114(55-60-142(251)252)156(267)230-130(83-146(259)260)160(271)209-96(12)151(262)233-133(88-241)181(292)239-71-27-37-137(239)174(285)216-117(58-63-145(257)258)157(268)214-116(57-62-144(255)256)158(269)220-121(73-91(4)5)162(273)228-128(81-139(189)248)167(278)213-111(31-21-65-201-183(192)193)154(265)223-124(76-100-40-48-106(244)49-41-100)165(276)224-123(75-99-38-46-105(243)47-39-99)159(270)208-95(11)150(261)232-132(87-240)170(281)222-120(72-90(2)3)161(272)212-112(32-22-66-202-184(194)195)155(266)227-127(80-104-85-200-89-207-104)166(277)225-125(77-101-42-50-107(245)51-43-101)164(275)221-122(74-92(6)7)163(274)229-129(82-140(190)249)168(279)226-126(79-103-84-205-110-29-18-17-28-109(103)110)169(280)234-148(93(8)9)176(287)235-149(98(14)242)177(288)217-113(33-23-67-203-185(196)197)153(264)218-119(54-59-138(188)247)179(290)236(15)134(34-24-68-204-186(198)199)172(283)231-131(182(293)294)78-102-44-52-108(246)53-45-102/h17-18,28-29,38-53,84-85,89-98,111-137,147-149,205,240-246H,16,19-27,30-37,54-83,86-88,187,191H2,1-15H3,(H2,188,247)(H2,189,248)(H2,190,249)(H,200,207)(H,206,282)(H,208,270)(H,209,271)(H,210,263)(H,211,250)(H,212,272)(H,213,278)(H,214,268)(H,215,284)(H,216,285)(H,217,288)(H,218,264)(H,219,286)(H,220,269)(H,221,275)(H,222,281)(H,223,265)(H,224,276)(H,225,277)(H,226,279)(H,227,266)(H,228,273)(H,229,274)(H,230,267)(H,231,283)(H,232,261)(H,233,262)(H,234,280)(H,235,287)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H,293,294)(H4,192,193,201)(H4,194,195,202)(H4,196,197,203)(H4,198,199,204)/t94-,95-,96-,97-,98+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,147-,148-,149-/m0/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [125I]-PYY(1 to 36 residues) from human Y5R expressed in HEK293 cell membranes after 2 hrs by scintillation proximity assay |
J Med Chem 61: 10519-10530 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50466542
(CHEMBL4290445)Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N(C)[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O |r| Show InChI InChI=1S/C186H279N53O55/c1-16-94(10)147(191)175(286)219-118(30-19-20-64-187)180(291)238-70-26-36-136(238)173(284)215-115(56-61-143(253)254)152(263)210-97(13)178(289)237-69-25-35-135(237)171(282)206-86-141(250)211-114(55-60-142(251)252)156(267)230-130(83-146(259)260)160(271)209-96(12)151(262)233-133(88-241)181(292)239-71-27-37-137(239)174(285)216-117(58-63-145(257)258)157(268)214-116(57-62-144(255)256)158(269)220-121(73-91(4)5)162(273)228-128(81-139(189)248)167(278)213-111(31-21-65-201-183(192)193)154(265)223-124(76-100-40-48-106(244)49-41-100)165(276)224-123(75-99-38-46-105(243)47-39-99)159(270)208-95(11)150(261)232-132(87-240)170(281)222-120(72-90(2)3)161(272)212-112(32-22-66-202-184(194)195)155(266)227-127(80-104-85-200-89-207-104)166(277)225-125(77-101-42-50-107(245)51-43-101)164(275)221-122(74-92(6)7)163(274)229-129(82-140(190)249)168(279)226-126(79-103-84-205-110-29-18-17-28-109(103)110)169(280)234-148(93(8)9)176(287)235-149(98(14)242)177(288)217-113(33-23-67-203-185(196)197)153(264)218-119(54-59-138(188)247)179(290)236(15)134(34-24-68-204-186(198)199)172(283)231-131(182(293)294)78-102-44-52-108(246)53-45-102/h17-18,28-29,38-53,84-85,89-98,111-137,147-149,205,240-246H,16,19-27,30-37,54-83,86-88,187,191H2,1-15H3,(H2,188,247)(H2,189,248)(H2,190,249)(H,200,207)(H,206,282)(H,208,270)(H,209,271)(H,210,263)(H,211,250)(H,212,272)(H,213,278)(H,214,268)(H,215,284)(H,216,285)(H,217,288)(H,218,264)(H,219,286)(H,220,269)(H,221,275)(H,222,281)(H,223,265)(H,224,276)(H,225,277)(H,226,279)(H,227,266)(H,228,273)(H,229,274)(H,230,267)(H,231,283)(H,232,261)(H,233,262)(H,234,280)(H,235,287)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H,293,294)(H4,192,193,201)(H4,194,195,202)(H4,196,197,203)(H4,198,199,204)/t94-,95-,96-,97-,98+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,147-,148-,149-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 790 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [125I]-PP from human Y4R expressed in CHO-K1 cell membranes after 2 hrs by scintillation proximity assay |
J Med Chem 61: 10519-10530 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50466542
(CHEMBL4290445)Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N(C)[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O |r| Show InChI InChI=1S/C186H279N53O55/c1-16-94(10)147(191)175(286)219-118(30-19-20-64-187)180(291)238-70-26-36-136(238)173(284)215-115(56-61-143(253)254)152(263)210-97(13)178(289)237-69-25-35-135(237)171(282)206-86-141(250)211-114(55-60-142(251)252)156(267)230-130(83-146(259)260)160(271)209-96(12)151(262)233-133(88-241)181(292)239-71-27-37-137(239)174(285)216-117(58-63-145(257)258)157(268)214-116(57-62-144(255)256)158(269)220-121(73-91(4)5)162(273)228-128(81-139(189)248)167(278)213-111(31-21-65-201-183(192)193)154(265)223-124(76-100-40-48-106(244)49-41-100)165(276)224-123(75-99-38-46-105(243)47-39-99)159(270)208-95(11)150(261)232-132(87-240)170(281)222-120(72-90(2)3)161(272)212-112(32-22-66-202-184(194)195)155(266)227-127(80-104-85-200-89-207-104)166(277)225-125(77-101-42-50-107(245)51-43-101)164(275)221-122(74-92(6)7)163(274)229-129(82-140(190)249)168(279)226-126(79-103-84-205-110-29-18-17-28-109(103)110)169(280)234-148(93(8)9)176(287)235-149(98(14)242)177(288)217-113(33-23-67-203-185(196)197)153(264)218-119(54-59-138(188)247)179(290)236(15)134(34-24-68-204-186(198)199)172(283)231-131(182(293)294)78-102-44-52-108(246)53-45-102/h17-18,28-29,38-53,84-85,89-98,111-137,147-149,205,240-246H,16,19-27,30-37,54-83,86-88,187,191H2,1-15H3,(H2,188,247)(H2,189,248)(H2,190,249)(H,200,207)(H,206,282)(H,208,270)(H,209,271)(H,210,263)(H,211,250)(H,212,272)(H,213,278)(H,214,268)(H,215,284)(H,216,285)(H,217,288)(H,218,264)(H,219,286)(H,220,269)(H,221,275)(H,222,281)(H,223,265)(H,224,276)(H,225,277)(H,226,279)(H,227,266)(H,228,273)(H,229,274)(H,230,267)(H,231,283)(H,232,261)(H,233,262)(H,234,280)(H,235,287)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H,293,294)(H4,192,193,201)(H4,194,195,202)(H4,196,197,203)(H4,198,199,204)/t94-,95-,96-,97-,98+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,147-,148-,149-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 794 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [125I]-PP from human Y4R expressed in CHO-K1 cell membranes after 2 hrs by scintillation proximity assay |
J Med Chem 61: 10519-10530 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 1
(Homo sapiens (Human)) | BDBM50466542
(CHEMBL4290445)Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N(C)[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O |r| Show InChI InChI=1S/C186H279N53O55/c1-16-94(10)147(191)175(286)219-118(30-19-20-64-187)180(291)238-70-26-36-136(238)173(284)215-115(56-61-143(253)254)152(263)210-97(13)178(289)237-69-25-35-135(237)171(282)206-86-141(250)211-114(55-60-142(251)252)156(267)230-130(83-146(259)260)160(271)209-96(12)151(262)233-133(88-241)181(292)239-71-27-37-137(239)174(285)216-117(58-63-145(257)258)157(268)214-116(57-62-144(255)256)158(269)220-121(73-91(4)5)162(273)228-128(81-139(189)248)167(278)213-111(31-21-65-201-183(192)193)154(265)223-124(76-100-40-48-106(244)49-41-100)165(276)224-123(75-99-38-46-105(243)47-39-99)159(270)208-95(11)150(261)232-132(87-240)170(281)222-120(72-90(2)3)161(272)212-112(32-22-66-202-184(194)195)155(266)227-127(80-104-85-200-89-207-104)166(277)225-125(77-101-42-50-107(245)51-43-101)164(275)221-122(74-92(6)7)163(274)229-129(82-140(190)249)168(279)226-126(79-103-84-205-110-29-18-17-28-109(103)110)169(280)234-148(93(8)9)176(287)235-149(98(14)242)177(288)217-113(33-23-67-203-185(196)197)153(264)218-119(54-59-138(188)247)179(290)236(15)134(34-24-68-204-186(198)199)172(283)231-131(182(293)294)78-102-44-52-108(246)53-45-102/h17-18,28-29,38-53,84-85,89-98,111-137,147-149,205,240-246H,16,19-27,30-37,54-83,86-88,187,191H2,1-15H3,(H2,188,247)(H2,189,248)(H2,190,249)(H,200,207)(H,206,282)(H,208,270)(H,209,271)(H,210,263)(H,211,250)(H,212,272)(H,213,278)(H,214,268)(H,215,284)(H,216,285)(H,217,288)(H,218,264)(H,219,286)(H,220,269)(H,221,275)(H,222,281)(H,223,265)(H,224,276)(H,225,277)(H,226,279)(H,227,266)(H,228,273)(H,229,274)(H,230,267)(H,231,283)(H,232,261)(H,233,262)(H,234,280)(H,235,287)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H,293,294)(H4,192,193,201)(H4,194,195,202)(H4,196,197,203)(H4,198,199,204)/t94-,95-,96-,97-,98+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,147-,148-,149-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay |
J Med Chem 61: 10519-10530 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 1
(Homo sapiens (Human)) | BDBM50466542
(CHEMBL4290445)Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N(C)[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O |r| Show InChI InChI=1S/C186H279N53O55/c1-16-94(10)147(191)175(286)219-118(30-19-20-64-187)180(291)238-70-26-36-136(238)173(284)215-115(56-61-143(253)254)152(263)210-97(13)178(289)237-69-25-35-135(237)171(282)206-86-141(250)211-114(55-60-142(251)252)156(267)230-130(83-146(259)260)160(271)209-96(12)151(262)233-133(88-241)181(292)239-71-27-37-137(239)174(285)216-117(58-63-145(257)258)157(268)214-116(57-62-144(255)256)158(269)220-121(73-91(4)5)162(273)228-128(81-139(189)248)167(278)213-111(31-21-65-201-183(192)193)154(265)223-124(76-100-40-48-106(244)49-41-100)165(276)224-123(75-99-38-46-105(243)47-39-99)159(270)208-95(11)150(261)232-132(87-240)170(281)222-120(72-90(2)3)161(272)212-112(32-22-66-202-184(194)195)155(266)227-127(80-104-85-200-89-207-104)166(277)225-125(77-101-42-50-107(245)51-43-101)164(275)221-122(74-92(6)7)163(274)229-129(82-140(190)249)168(279)226-126(79-103-84-205-110-29-18-17-28-109(103)110)169(280)234-148(93(8)9)176(287)235-149(98(14)242)177(288)217-113(33-23-67-203-185(196)197)153(264)218-119(54-59-138(188)247)179(290)236(15)134(34-24-68-204-186(198)199)172(283)231-131(182(293)294)78-102-44-52-108(246)53-45-102/h17-18,28-29,38-53,84-85,89-98,111-137,147-149,205,240-246H,16,19-27,30-37,54-83,86-88,187,191H2,1-15H3,(H2,188,247)(H2,189,248)(H2,190,249)(H,200,207)(H,206,282)(H,208,270)(H,209,271)(H,210,263)(H,211,250)(H,212,272)(H,213,278)(H,214,268)(H,215,284)(H,216,285)(H,217,288)(H,218,264)(H,219,286)(H,220,269)(H,221,275)(H,222,281)(H,223,265)(H,224,276)(H,225,277)(H,226,279)(H,227,266)(H,228,273)(H,229,274)(H,230,267)(H,231,283)(H,232,261)(H,233,262)(H,234,280)(H,235,287)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H,293,294)(H4,192,193,201)(H4,194,195,202)(H4,196,197,203)(H4,198,199,204)/t94-,95-,96-,97-,98+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,147-,148-,149-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 2.51E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay |
J Med Chem 61: 10519-10530 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50466542
(CHEMBL4290445)Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N(C)[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O |r| Show InChI InChI=1S/C186H279N53O55/c1-16-94(10)147(191)175(286)219-118(30-19-20-64-187)180(291)238-70-26-36-136(238)173(284)215-115(56-61-143(253)254)152(263)210-97(13)178(289)237-69-25-35-135(237)171(282)206-86-141(250)211-114(55-60-142(251)252)156(267)230-130(83-146(259)260)160(271)209-96(12)151(262)233-133(88-241)181(292)239-71-27-37-137(239)174(285)216-117(58-63-145(257)258)157(268)214-116(57-62-144(255)256)158(269)220-121(73-91(4)5)162(273)228-128(81-139(189)248)167(278)213-111(31-21-65-201-183(192)193)154(265)223-124(76-100-40-48-106(244)49-41-100)165(276)224-123(75-99-38-46-105(243)47-39-99)159(270)208-95(11)150(261)232-132(87-240)170(281)222-120(72-90(2)3)161(272)212-112(32-22-66-202-184(194)195)155(266)227-127(80-104-85-200-89-207-104)166(277)225-125(77-101-42-50-107(245)51-43-101)164(275)221-122(74-92(6)7)163(274)229-129(82-140(190)249)168(279)226-126(79-103-84-205-110-29-18-17-28-109(103)110)169(280)234-148(93(8)9)176(287)235-149(98(14)242)177(288)217-113(33-23-67-203-185(196)197)153(264)218-119(54-59-138(188)247)179(290)236(15)134(34-24-68-204-186(198)199)172(283)231-131(182(293)294)78-102-44-52-108(246)53-45-102/h17-18,28-29,38-53,84-85,89-98,111-137,147-149,205,240-246H,16,19-27,30-37,54-83,86-88,187,191H2,1-15H3,(H2,188,247)(H2,189,248)(H2,190,249)(H,200,207)(H,206,282)(H,208,270)(H,209,271)(H,210,263)(H,211,250)(H,212,272)(H,213,278)(H,214,268)(H,215,284)(H,216,285)(H,217,288)(H,218,264)(H,219,286)(H,220,269)(H,221,275)(H,222,281)(H,223,265)(H,224,276)(H,225,277)(H,226,279)(H,227,266)(H,228,273)(H,229,274)(H,230,267)(H,231,283)(H,232,261)(H,233,262)(H,234,280)(H,235,287)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H,293,294)(H4,192,193,201)(H4,194,195,202)(H4,196,197,203)(H4,198,199,204)/t94-,95-,96-,97-,98+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,147-,148-,149-/m0/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 158 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Activation of human Y5R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ... |
J Med Chem 61: 10519-10530 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Mus musculus) | BDBM50466542
(CHEMBL4290445)Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N(C)[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O |r| Show InChI InChI=1S/C186H279N53O55/c1-16-94(10)147(191)175(286)219-118(30-19-20-64-187)180(291)238-70-26-36-136(238)173(284)215-115(56-61-143(253)254)152(263)210-97(13)178(289)237-69-25-35-135(237)171(282)206-86-141(250)211-114(55-60-142(251)252)156(267)230-130(83-146(259)260)160(271)209-96(12)151(262)233-133(88-241)181(292)239-71-27-37-137(239)174(285)216-117(58-63-145(257)258)157(268)214-116(57-62-144(255)256)158(269)220-121(73-91(4)5)162(273)228-128(81-139(189)248)167(278)213-111(31-21-65-201-183(192)193)154(265)223-124(76-100-40-48-106(244)49-41-100)165(276)224-123(75-99-38-46-105(243)47-39-99)159(270)208-95(11)150(261)232-132(87-240)170(281)222-120(72-90(2)3)161(272)212-112(32-22-66-202-184(194)195)155(266)227-127(80-104-85-200-89-207-104)166(277)225-125(77-101-42-50-107(245)51-43-101)164(275)221-122(74-92(6)7)163(274)229-129(82-140(190)249)168(279)226-126(79-103-84-205-110-29-18-17-28-109(103)110)169(280)234-148(93(8)9)176(287)235-149(98(14)242)177(288)217-113(33-23-67-203-185(196)197)153(264)218-119(54-59-138(188)247)179(290)236(15)134(34-24-68-204-186(198)199)172(283)231-131(182(293)294)78-102-44-52-108(246)53-45-102/h17-18,28-29,38-53,84-85,89-98,111-137,147-149,205,240-246H,16,19-27,30-37,54-83,86-88,187,191H2,1-15H3,(H2,188,247)(H2,189,248)(H2,190,249)(H,200,207)(H,206,282)(H,208,270)(H,209,271)(H,210,263)(H,211,250)(H,212,272)(H,213,278)(H,214,268)(H,215,284)(H,216,285)(H,217,288)(H,218,264)(H,219,286)(H,220,269)(H,221,275)(H,222,281)(H,223,265)(H,224,276)(H,225,277)(H,226,279)(H,227,266)(H,228,273)(H,229,274)(H,230,267)(H,231,283)(H,232,261)(H,233,262)(H,234,280)(H,235,287)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H,293,294)(H4,192,193,201)(H4,194,195,202)(H4,196,197,203)(H4,198,199,204)/t94-,95-,96-,97-,98+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,147-,148-,149-/m0/s1 | UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [125I]-PYY(1 to 36 residues) from mouse Y4R expressed in HEK293 cell membranes after 2 hrs by scintillation proximity assay |
J Med Chem 61: 10519-10530 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Mus musculus (Mouse)) | BDBM50466542
(CHEMBL4290445)Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N(C)[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O |r| Show InChI InChI=1S/C186H279N53O55/c1-16-94(10)147(191)175(286)219-118(30-19-20-64-187)180(291)238-70-26-36-136(238)173(284)215-115(56-61-143(253)254)152(263)210-97(13)178(289)237-69-25-35-135(237)171(282)206-86-141(250)211-114(55-60-142(251)252)156(267)230-130(83-146(259)260)160(271)209-96(12)151(262)233-133(88-241)181(292)239-71-27-37-137(239)174(285)216-117(58-63-145(257)258)157(268)214-116(57-62-144(255)256)158(269)220-121(73-91(4)5)162(273)228-128(81-139(189)248)167(278)213-111(31-21-65-201-183(192)193)154(265)223-124(76-100-40-48-106(244)49-41-100)165(276)224-123(75-99-38-46-105(243)47-39-99)159(270)208-95(11)150(261)232-132(87-240)170(281)222-120(72-90(2)3)161(272)212-112(32-22-66-202-184(194)195)155(266)227-127(80-104-85-200-89-207-104)166(277)225-125(77-101-42-50-107(245)51-43-101)164(275)221-122(74-92(6)7)163(274)229-129(82-140(190)249)168(279)226-126(79-103-84-205-110-29-18-17-28-109(103)110)169(280)234-148(93(8)9)176(287)235-149(98(14)242)177(288)217-113(33-23-67-203-185(196)197)153(264)218-119(54-59-138(188)247)179(290)236(15)134(34-24-68-204-186(198)199)172(283)231-131(182(293)294)78-102-44-52-108(246)53-45-102/h17-18,28-29,38-53,84-85,89-98,111-137,147-149,205,240-246H,16,19-27,30-37,54-83,86-88,187,191H2,1-15H3,(H2,188,247)(H2,189,248)(H2,190,249)(H,200,207)(H,206,282)(H,208,270)(H,209,271)(H,210,263)(H,211,250)(H,212,272)(H,213,278)(H,214,268)(H,215,284)(H,216,285)(H,217,288)(H,218,264)(H,219,286)(H,220,269)(H,221,275)(H,222,281)(H,223,265)(H,224,276)(H,225,277)(H,226,279)(H,227,266)(H,228,273)(H,229,274)(H,230,267)(H,231,283)(H,232,261)(H,233,262)(H,234,280)(H,235,287)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H,293,294)(H4,192,193,201)(H4,194,195,202)(H4,196,197,203)(H4,198,199,204)/t94-,95-,96-,97-,98+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,147-,148-,149-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 630 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [125I]-PYY(1 to 36 residues) from mouse Y5R expressed in HEK293 cell membranes after 2 hrs by scintillation proximity assay |
J Med Chem 61: 10519-10530 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50466542
(CHEMBL4290445)Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N(C)[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O |r| Show InChI InChI=1S/C186H279N53O55/c1-16-94(10)147(191)175(286)219-118(30-19-20-64-187)180(291)238-70-26-36-136(238)173(284)215-115(56-61-143(253)254)152(263)210-97(13)178(289)237-69-25-35-135(237)171(282)206-86-141(250)211-114(55-60-142(251)252)156(267)230-130(83-146(259)260)160(271)209-96(12)151(262)233-133(88-241)181(292)239-71-27-37-137(239)174(285)216-117(58-63-145(257)258)157(268)214-116(57-62-144(255)256)158(269)220-121(73-91(4)5)162(273)228-128(81-139(189)248)167(278)213-111(31-21-65-201-183(192)193)154(265)223-124(76-100-40-48-106(244)49-41-100)165(276)224-123(75-99-38-46-105(243)47-39-99)159(270)208-95(11)150(261)232-132(87-240)170(281)222-120(72-90(2)3)161(272)212-112(32-22-66-202-184(194)195)155(266)227-127(80-104-85-200-89-207-104)166(277)225-125(77-101-42-50-107(245)51-43-101)164(275)221-122(74-92(6)7)163(274)229-129(82-140(190)249)168(279)226-126(79-103-84-205-110-29-18-17-28-109(103)110)169(280)234-148(93(8)9)176(287)235-149(98(14)242)177(288)217-113(33-23-67-203-185(196)197)153(264)218-119(54-59-138(188)247)179(290)236(15)134(34-24-68-204-186(198)199)172(283)231-131(182(293)294)78-102-44-52-108(246)53-45-102/h17-18,28-29,38-53,84-85,89-98,111-137,147-149,205,240-246H,16,19-27,30-37,54-83,86-88,187,191H2,1-15H3,(H2,188,247)(H2,189,248)(H2,190,249)(H,200,207)(H,206,282)(H,208,270)(H,209,271)(H,210,263)(H,211,250)(H,212,272)(H,213,278)(H,214,268)(H,215,284)(H,216,285)(H,217,288)(H,218,264)(H,219,286)(H,220,269)(H,221,275)(H,222,281)(H,223,265)(H,224,276)(H,225,277)(H,226,279)(H,227,266)(H,228,273)(H,229,274)(H,230,267)(H,231,283)(H,232,261)(H,233,262)(H,234,280)(H,235,287)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H,293,294)(H4,192,193,201)(H4,194,195,202)(H4,196,197,203)(H4,198,199,204)/t94-,95-,96-,97-,98+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,147-,148-,149-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Activation of human Y4R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ... |
J Med Chem 61: 10519-10530 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM50466542
(CHEMBL4290445)Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N(C)[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O |r| Show InChI InChI=1S/C186H279N53O55/c1-16-94(10)147(191)175(286)219-118(30-19-20-64-187)180(291)238-70-26-36-136(238)173(284)215-115(56-61-143(253)254)152(263)210-97(13)178(289)237-69-25-35-135(237)171(282)206-86-141(250)211-114(55-60-142(251)252)156(267)230-130(83-146(259)260)160(271)209-96(12)151(262)233-133(88-241)181(292)239-71-27-37-137(239)174(285)216-117(58-63-145(257)258)157(268)214-116(57-62-144(255)256)158(269)220-121(73-91(4)5)162(273)228-128(81-139(189)248)167(278)213-111(31-21-65-201-183(192)193)154(265)223-124(76-100-40-48-106(244)49-41-100)165(276)224-123(75-99-38-46-105(243)47-39-99)159(270)208-95(11)150(261)232-132(87-240)170(281)222-120(72-90(2)3)161(272)212-112(32-22-66-202-184(194)195)155(266)227-127(80-104-85-200-89-207-104)166(277)225-125(77-101-42-50-107(245)51-43-101)164(275)221-122(74-92(6)7)163(274)229-129(82-140(190)249)168(279)226-126(79-103-84-205-110-29-18-17-28-109(103)110)169(280)234-148(93(8)9)176(287)235-149(98(14)242)177(288)217-113(33-23-67-203-185(196)197)153(264)218-119(54-59-138(188)247)179(290)236(15)134(34-24-68-204-186(198)199)172(283)231-131(182(293)294)78-102-44-52-108(246)53-45-102/h17-18,28-29,38-53,84-85,89-98,111-137,147-149,205,240-246H,16,19-27,30-37,54-83,86-88,187,191H2,1-15H3,(H2,188,247)(H2,189,248)(H2,190,249)(H,200,207)(H,206,282)(H,208,270)(H,209,271)(H,210,263)(H,211,250)(H,212,272)(H,213,278)(H,214,268)(H,215,284)(H,216,285)(H,217,288)(H,218,264)(H,219,286)(H,220,269)(H,221,275)(H,222,281)(H,223,265)(H,224,276)(H,225,277)(H,226,279)(H,227,266)(H,228,273)(H,229,274)(H,230,267)(H,231,283)(H,232,261)(H,233,262)(H,234,280)(H,235,287)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H,293,294)(H4,192,193,201)(H4,194,195,202)(H4,196,197,203)(H4,198,199,204)/t94-,95-,96-,97-,98+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,147-,148-,149-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Activation of human Y2R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ... |
J Med Chem 61: 10519-10530 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50466542
(CHEMBL4290445)Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N(C)[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O |r| Show InChI InChI=1S/C186H279N53O55/c1-16-94(10)147(191)175(286)219-118(30-19-20-64-187)180(291)238-70-26-36-136(238)173(284)215-115(56-61-143(253)254)152(263)210-97(13)178(289)237-69-25-35-135(237)171(282)206-86-141(250)211-114(55-60-142(251)252)156(267)230-130(83-146(259)260)160(271)209-96(12)151(262)233-133(88-241)181(292)239-71-27-37-137(239)174(285)216-117(58-63-145(257)258)157(268)214-116(57-62-144(255)256)158(269)220-121(73-91(4)5)162(273)228-128(81-139(189)248)167(278)213-111(31-21-65-201-183(192)193)154(265)223-124(76-100-40-48-106(244)49-41-100)165(276)224-123(75-99-38-46-105(243)47-39-99)159(270)208-95(11)150(261)232-132(87-240)170(281)222-120(72-90(2)3)161(272)212-112(32-22-66-202-184(194)195)155(266)227-127(80-104-85-200-89-207-104)166(277)225-125(77-101-42-50-107(245)51-43-101)164(275)221-122(74-92(6)7)163(274)229-129(82-140(190)249)168(279)226-126(79-103-84-205-110-29-18-17-28-109(103)110)169(280)234-148(93(8)9)176(287)235-149(98(14)242)177(288)217-113(33-23-67-203-185(196)197)153(264)218-119(54-59-138(188)247)179(290)236(15)134(34-24-68-204-186(198)199)172(283)231-131(182(293)294)78-102-44-52-108(246)53-45-102/h17-18,28-29,38-53,84-85,89-98,111-137,147-149,205,240-246H,16,19-27,30-37,54-83,86-88,187,191H2,1-15H3,(H2,188,247)(H2,189,248)(H2,190,249)(H,200,207)(H,206,282)(H,208,270)(H,209,271)(H,210,263)(H,211,250)(H,212,272)(H,213,278)(H,214,268)(H,215,284)(H,216,285)(H,217,288)(H,218,264)(H,219,286)(H,220,269)(H,221,275)(H,222,281)(H,223,265)(H,224,276)(H,225,277)(H,226,279)(H,227,266)(H,228,273)(H,229,274)(H,230,267)(H,231,283)(H,232,261)(H,233,262)(H,234,280)(H,235,287)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H,293,294)(H4,192,193,201)(H4,194,195,202)(H4,196,197,203)(H4,198,199,204)/t94-,95-,96-,97-,98+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,147-,148-,149-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Activation of human Y4R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ... |
J Med Chem 61: 10519-10530 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM50466542
(CHEMBL4290445)Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N(C)[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O |r| Show InChI InChI=1S/C186H279N53O55/c1-16-94(10)147(191)175(286)219-118(30-19-20-64-187)180(291)238-70-26-36-136(238)173(284)215-115(56-61-143(253)254)152(263)210-97(13)178(289)237-69-25-35-135(237)171(282)206-86-141(250)211-114(55-60-142(251)252)156(267)230-130(83-146(259)260)160(271)209-96(12)151(262)233-133(88-241)181(292)239-71-27-37-137(239)174(285)216-117(58-63-145(257)258)157(268)214-116(57-62-144(255)256)158(269)220-121(73-91(4)5)162(273)228-128(81-139(189)248)167(278)213-111(31-21-65-201-183(192)193)154(265)223-124(76-100-40-48-106(244)49-41-100)165(276)224-123(75-99-38-46-105(243)47-39-99)159(270)208-95(11)150(261)232-132(87-240)170(281)222-120(72-90(2)3)161(272)212-112(32-22-66-202-184(194)195)155(266)227-127(80-104-85-200-89-207-104)166(277)225-125(77-101-42-50-107(245)51-43-101)164(275)221-122(74-92(6)7)163(274)229-129(82-140(190)249)168(279)226-126(79-103-84-205-110-29-18-17-28-109(103)110)169(280)234-148(93(8)9)176(287)235-149(98(14)242)177(288)217-113(33-23-67-203-185(196)197)153(264)218-119(54-59-138(188)247)179(290)236(15)134(34-24-68-204-186(198)199)172(283)231-131(182(293)294)78-102-44-52-108(246)53-45-102/h17-18,28-29,38-53,84-85,89-98,111-137,147-149,205,240-246H,16,19-27,30-37,54-83,86-88,187,191H2,1-15H3,(H2,188,247)(H2,189,248)(H2,190,249)(H,200,207)(H,206,282)(H,208,270)(H,209,271)(H,210,263)(H,211,250)(H,212,272)(H,213,278)(H,214,268)(H,215,284)(H,216,285)(H,217,288)(H,218,264)(H,219,286)(H,220,269)(H,221,275)(H,222,281)(H,223,265)(H,224,276)(H,225,277)(H,226,279)(H,227,266)(H,228,273)(H,229,274)(H,230,267)(H,231,283)(H,232,261)(H,233,262)(H,234,280)(H,235,287)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H,293,294)(H4,192,193,201)(H4,194,195,202)(H4,196,197,203)(H4,198,199,204)/t94-,95-,96-,97-,98+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,147-,148-,149-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Activation of human Y2R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ... |
J Med Chem 61: 10519-10530 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 1
(Homo sapiens (Human)) | BDBM50466542
(CHEMBL4290445)Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N(C)[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O |r| Show InChI InChI=1S/C186H279N53O55/c1-16-94(10)147(191)175(286)219-118(30-19-20-64-187)180(291)238-70-26-36-136(238)173(284)215-115(56-61-143(253)254)152(263)210-97(13)178(289)237-69-25-35-135(237)171(282)206-86-141(250)211-114(55-60-142(251)252)156(267)230-130(83-146(259)260)160(271)209-96(12)151(262)233-133(88-241)181(292)239-71-27-37-137(239)174(285)216-117(58-63-145(257)258)157(268)214-116(57-62-144(255)256)158(269)220-121(73-91(4)5)162(273)228-128(81-139(189)248)167(278)213-111(31-21-65-201-183(192)193)154(265)223-124(76-100-40-48-106(244)49-41-100)165(276)224-123(75-99-38-46-105(243)47-39-99)159(270)208-95(11)150(261)232-132(87-240)170(281)222-120(72-90(2)3)161(272)212-112(32-22-66-202-184(194)195)155(266)227-127(80-104-85-200-89-207-104)166(277)225-125(77-101-42-50-107(245)51-43-101)164(275)221-122(74-92(6)7)163(274)229-129(82-140(190)249)168(279)226-126(79-103-84-205-110-29-18-17-28-109(103)110)169(280)234-148(93(8)9)176(287)235-149(98(14)242)177(288)217-113(33-23-67-203-185(196)197)153(264)218-119(54-59-138(188)247)179(290)236(15)134(34-24-68-204-186(198)199)172(283)231-131(182(293)294)78-102-44-52-108(246)53-45-102/h17-18,28-29,38-53,84-85,89-98,111-137,147-149,205,240-246H,16,19-27,30-37,54-83,86-88,187,191H2,1-15H3,(H2,188,247)(H2,189,248)(H2,190,249)(H,200,207)(H,206,282)(H,208,270)(H,209,271)(H,210,263)(H,211,250)(H,212,272)(H,213,278)(H,214,268)(H,215,284)(H,216,285)(H,217,288)(H,218,264)(H,219,286)(H,220,269)(H,221,275)(H,222,281)(H,223,265)(H,224,276)(H,225,277)(H,226,279)(H,227,266)(H,228,273)(H,229,274)(H,230,267)(H,231,283)(H,232,261)(H,233,262)(H,234,280)(H,235,287)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H,293,294)(H4,192,193,201)(H4,194,195,202)(H4,196,197,203)(H4,198,199,204)/t94-,95-,96-,97-,98+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,147-,148-,149-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ... |
J Med Chem 61: 10519-10530 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Mus musculus) | BDBM50466542
(CHEMBL4290445)Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N(C)[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O |r| Show InChI InChI=1S/C186H279N53O55/c1-16-94(10)147(191)175(286)219-118(30-19-20-64-187)180(291)238-70-26-36-136(238)173(284)215-115(56-61-143(253)254)152(263)210-97(13)178(289)237-69-25-35-135(237)171(282)206-86-141(250)211-114(55-60-142(251)252)156(267)230-130(83-146(259)260)160(271)209-96(12)151(262)233-133(88-241)181(292)239-71-27-37-137(239)174(285)216-117(58-63-145(257)258)157(268)214-116(57-62-144(255)256)158(269)220-121(73-91(4)5)162(273)228-128(81-139(189)248)167(278)213-111(31-21-65-201-183(192)193)154(265)223-124(76-100-40-48-106(244)49-41-100)165(276)224-123(75-99-38-46-105(243)47-39-99)159(270)208-95(11)150(261)232-132(87-240)170(281)222-120(72-90(2)3)161(272)212-112(32-22-66-202-184(194)195)155(266)227-127(80-104-85-200-89-207-104)166(277)225-125(77-101-42-50-107(245)51-43-101)164(275)221-122(74-92(6)7)163(274)229-129(82-140(190)249)168(279)226-126(79-103-84-205-110-29-18-17-28-109(103)110)169(280)234-148(93(8)9)176(287)235-149(98(14)242)177(288)217-113(33-23-67-203-185(196)197)153(264)218-119(54-59-138(188)247)179(290)236(15)134(34-24-68-204-186(198)199)172(283)231-131(182(293)294)78-102-44-52-108(246)53-45-102/h17-18,28-29,38-53,84-85,89-98,111-137,147-149,205,240-246H,16,19-27,30-37,54-83,86-88,187,191H2,1-15H3,(H2,188,247)(H2,189,248)(H2,190,249)(H,200,207)(H,206,282)(H,208,270)(H,209,271)(H,210,263)(H,211,250)(H,212,272)(H,213,278)(H,214,268)(H,215,284)(H,216,285)(H,217,288)(H,218,264)(H,219,286)(H,220,269)(H,221,275)(H,222,281)(H,223,265)(H,224,276)(H,225,277)(H,226,279)(H,227,266)(H,228,273)(H,229,274)(H,230,267)(H,231,283)(H,232,261)(H,233,262)(H,234,280)(H,235,287)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H,293,294)(H4,192,193,201)(H4,194,195,202)(H4,196,197,203)(H4,198,199,204)/t94-,95-,96-,97-,98+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,147-,148-,149-/m0/s1 | UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [125I]-PYY(1 to 36 residues) from mouse Y4R expressed in HEK293 cell membranes after 2 hrs by scintillation proximity assay |
J Med Chem 61: 10519-10530 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Mus musculus (Mouse)) | BDBM50466542
(CHEMBL4290445)Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N(C)[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O |r| Show InChI InChI=1S/C186H279N53O55/c1-16-94(10)147(191)175(286)219-118(30-19-20-64-187)180(291)238-70-26-36-136(238)173(284)215-115(56-61-143(253)254)152(263)210-97(13)178(289)237-69-25-35-135(237)171(282)206-86-141(250)211-114(55-60-142(251)252)156(267)230-130(83-146(259)260)160(271)209-96(12)151(262)233-133(88-241)181(292)239-71-27-37-137(239)174(285)216-117(58-63-145(257)258)157(268)214-116(57-62-144(255)256)158(269)220-121(73-91(4)5)162(273)228-128(81-139(189)248)167(278)213-111(31-21-65-201-183(192)193)154(265)223-124(76-100-40-48-106(244)49-41-100)165(276)224-123(75-99-38-46-105(243)47-39-99)159(270)208-95(11)150(261)232-132(87-240)170(281)222-120(72-90(2)3)161(272)212-112(32-22-66-202-184(194)195)155(266)227-127(80-104-85-200-89-207-104)166(277)225-125(77-101-42-50-107(245)51-43-101)164(275)221-122(74-92(6)7)163(274)229-129(82-140(190)249)168(279)226-126(79-103-84-205-110-29-18-17-28-109(103)110)169(280)234-148(93(8)9)176(287)235-149(98(14)242)177(288)217-113(33-23-67-203-185(196)197)153(264)218-119(54-59-138(188)247)179(290)236(15)134(34-24-68-204-186(198)199)172(283)231-131(182(293)294)78-102-44-52-108(246)53-45-102/h17-18,28-29,38-53,84-85,89-98,111-137,147-149,205,240-246H,16,19-27,30-37,54-83,86-88,187,191H2,1-15H3,(H2,188,247)(H2,189,248)(H2,190,249)(H,200,207)(H,206,282)(H,208,270)(H,209,271)(H,210,263)(H,211,250)(H,212,272)(H,213,278)(H,214,268)(H,215,284)(H,216,285)(H,217,288)(H,218,264)(H,219,286)(H,220,269)(H,221,275)(H,222,281)(H,223,265)(H,224,276)(H,225,277)(H,226,279)(H,227,266)(H,228,273)(H,229,274)(H,230,267)(H,231,283)(H,232,261)(H,233,262)(H,234,280)(H,235,287)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H,293,294)(H4,192,193,201)(H4,194,195,202)(H4,196,197,203)(H4,198,199,204)/t94-,95-,96-,97-,98+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,147-,148-,149-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 631 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [125I]-PYY(1 to 36 residues) from mouse Y5R expressed in HEK293 cell membranes after 2 hrs by scintillation proximity assay |
J Med Chem 61: 10519-10530 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 1
(Homo sapiens (Human)) | BDBM50466542
(CHEMBL4290445)Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N(C)[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O |r| Show InChI InChI=1S/C186H279N53O55/c1-16-94(10)147(191)175(286)219-118(30-19-20-64-187)180(291)238-70-26-36-136(238)173(284)215-115(56-61-143(253)254)152(263)210-97(13)178(289)237-69-25-35-135(237)171(282)206-86-141(250)211-114(55-60-142(251)252)156(267)230-130(83-146(259)260)160(271)209-96(12)151(262)233-133(88-241)181(292)239-71-27-37-137(239)174(285)216-117(58-63-145(257)258)157(268)214-116(57-62-144(255)256)158(269)220-121(73-91(4)5)162(273)228-128(81-139(189)248)167(278)213-111(31-21-65-201-183(192)193)154(265)223-124(76-100-40-48-106(244)49-41-100)165(276)224-123(75-99-38-46-105(243)47-39-99)159(270)208-95(11)150(261)232-132(87-240)170(281)222-120(72-90(2)3)161(272)212-112(32-22-66-202-184(194)195)155(266)227-127(80-104-85-200-89-207-104)166(277)225-125(77-101-42-50-107(245)51-43-101)164(275)221-122(74-92(6)7)163(274)229-129(82-140(190)249)168(279)226-126(79-103-84-205-110-29-18-17-28-109(103)110)169(280)234-148(93(8)9)176(287)235-149(98(14)242)177(288)217-113(33-23-67-203-185(196)197)153(264)218-119(54-59-138(188)247)179(290)236(15)134(34-24-68-204-186(198)199)172(283)231-131(182(293)294)78-102-44-52-108(246)53-45-102/h17-18,28-29,38-53,84-85,89-98,111-137,147-149,205,240-246H,16,19-27,30-37,54-83,86-88,187,191H2,1-15H3,(H2,188,247)(H2,189,248)(H2,190,249)(H,200,207)(H,206,282)(H,208,270)(H,209,271)(H,210,263)(H,211,250)(H,212,272)(H,213,278)(H,214,268)(H,215,284)(H,216,285)(H,217,288)(H,218,264)(H,219,286)(H,220,269)(H,221,275)(H,222,281)(H,223,265)(H,224,276)(H,225,277)(H,226,279)(H,227,266)(H,228,273)(H,229,274)(H,230,267)(H,231,283)(H,232,261)(H,233,262)(H,234,280)(H,235,287)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H,293,294)(H4,192,193,201)(H4,194,195,202)(H4,196,197,203)(H4,198,199,204)/t94-,95-,96-,97-,98+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,147-,148-,149-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ... |
J Med Chem 61: 10519-10530 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50466542
(CHEMBL4290445)Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N(C)[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O |r| Show InChI InChI=1S/C186H279N53O55/c1-16-94(10)147(191)175(286)219-118(30-19-20-64-187)180(291)238-70-26-36-136(238)173(284)215-115(56-61-143(253)254)152(263)210-97(13)178(289)237-69-25-35-135(237)171(282)206-86-141(250)211-114(55-60-142(251)252)156(267)230-130(83-146(259)260)160(271)209-96(12)151(262)233-133(88-241)181(292)239-71-27-37-137(239)174(285)216-117(58-63-145(257)258)157(268)214-116(57-62-144(255)256)158(269)220-121(73-91(4)5)162(273)228-128(81-139(189)248)167(278)213-111(31-21-65-201-183(192)193)154(265)223-124(76-100-40-48-106(244)49-41-100)165(276)224-123(75-99-38-46-105(243)47-39-99)159(270)208-95(11)150(261)232-132(87-240)170(281)222-120(72-90(2)3)161(272)212-112(32-22-66-202-184(194)195)155(266)227-127(80-104-85-200-89-207-104)166(277)225-125(77-101-42-50-107(245)51-43-101)164(275)221-122(74-92(6)7)163(274)229-129(82-140(190)249)168(279)226-126(79-103-84-205-110-29-18-17-28-109(103)110)169(280)234-148(93(8)9)176(287)235-149(98(14)242)177(288)217-113(33-23-67-203-185(196)197)153(264)218-119(54-59-138(188)247)179(290)236(15)134(34-24-68-204-186(198)199)172(283)231-131(182(293)294)78-102-44-52-108(246)53-45-102/h17-18,28-29,38-53,84-85,89-98,111-137,147-149,205,240-246H,16,19-27,30-37,54-83,86-88,187,191H2,1-15H3,(H2,188,247)(H2,189,248)(H2,190,249)(H,200,207)(H,206,282)(H,208,270)(H,209,271)(H,210,263)(H,211,250)(H,212,272)(H,213,278)(H,214,268)(H,215,284)(H,216,285)(H,217,288)(H,218,264)(H,219,286)(H,220,269)(H,221,275)(H,222,281)(H,223,265)(H,224,276)(H,225,277)(H,226,279)(H,227,266)(H,228,273)(H,229,274)(H,230,267)(H,231,283)(H,232,261)(H,233,262)(H,234,280)(H,235,287)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H,293,294)(H4,192,193,201)(H4,194,195,202)(H4,196,197,203)(H4,198,199,204)/t94-,95-,96-,97-,98+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,147-,148-,149-/m0/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 160 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Activation of human Y5R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ... |
J Med Chem 61: 10519-10530 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01046
BindingDB Entry DOI: 10.7270/Q2ZC85JC |
More data for this
Ligand-Target Pair | |
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