BDBM50467663 CHEMBL4285153

SMILES: CCOc1ccnc(COc2ccc(cc2-c2ccc3CCNCCc3c2)C(C)=O)c1

InChI Key: InChIKey=HFPHJFBAGWOOFH-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50467663   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aurora B/Incenp (Homo sapiens (Human))	BDBM50467663 (CHEMBL4285153) Show SMILES CCOc1ccnc(COc2ccc(cc2-c2ccc3CCNCCc3c2)C(C)=O)c1 Show InChI InChI=1S/C26H28N2O3/c1-3-30-24-10-13-28-23(16-24)17-31-26-7-6-20(18(2)29)15-25(26)22-5-4-19-8-11-27-12-9-21(19)14-22/h4-7,10,13-16,27H,3,8-9,11-12,17H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.98E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline R&D Curated by ChEMBL					Assay Description Inhibition of recombinant human FLAG/His6-tagged Aurora-B (2 to 344 residues)/GST-tagged INCENP preincubated for 30 mins followed by 5FAM-PKA-tide su...				Bioorg Med Chem Lett 28: 3458-3462 (2018) Article DOI: 10.1016/j.bmcl.2018.09.022 BindingDB Entry DOI: 10.7270/Q2X3515K
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50467663 (CHEMBL4285153) Show SMILES CCOc1ccnc(COc2ccc(cc2-c2ccc3CCNCCc3c2)C(C)=O)c1 Show InChI InChI=1S/C26H28N2O3/c1-3-30-24-10-13-28-23(16-24)17-31-26-7-6-20(18(2)29)15-25(26)22-5-4-19-8-11-27-12-9-21(19)14-22/h4-7,10,13-16,27H,3,8-9,11-12,17H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	631	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline R&D Curated by ChEMBL					Assay Description Inhibition of SYK in human Ramos B cells assessed as reduction in anti-human IgM Fab2 fragment-induced ERK phosphorylation preincubated for 30 mins f...				Bioorg Med Chem Lett 28: 3458-3462 (2018) Article DOI: 10.1016/j.bmcl.2018.09.022 BindingDB Entry DOI: 10.7270/Q2X3515K
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50467663 (CHEMBL4285153) Show SMILES CCOc1ccnc(COc2ccc(cc2-c2ccc3CCNCCc3c2)C(C)=O)c1 Show InChI InChI=1S/C26H28N2O3/c1-3-30-24-10-13-28-23(16-24)17-31-26-7-6-20(18(2)29)15-25(26)22-5-4-19-8-11-27-12-9-21(19)14-22/h4-7,10,13-16,27H,3,8-9,11-12,17H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline R&D Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal His6-tagged SYK expressed in baculovirus expression system using Biotin-AAAEEIYGEI as substrate after 60 m...				Bioorg Med Chem Lett 28: 3458-3462 (2018) Article DOI: 10.1016/j.bmcl.2018.09.022 BindingDB Entry DOI: 10.7270/Q2X3515K
					More data for this Ligand-Target Pair