BDBM50467675 CHEMBL4280620

SMILES: CC(=O)c1ccc(OCc2ccccn2)c(c1)-c1ccc2CCNCCc2c1

InChI Key: InChIKey=SMCVDPXIAQLLPB-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50467675   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aurora B/Incenp (Homo sapiens (Human))	BDBM50467675 (CHEMBL4280620) Show SMILES CC(=O)c1ccc(OCc2ccccn2)c(c1)-c1ccc2CCNCCc2c1 Show InChI InChI=1S/C24H24N2O2/c1-17(27)19-7-8-24(28-16-22-4-2-3-11-26-22)23(15-19)21-6-5-18-9-12-25-13-10-20(18)14-21/h2-8,11,14-15,25H,9-10,12-13,16H2,1H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	<2.51E+4	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline R&D Curated by ChEMBL					Assay Description Inhibition of recombinant human FLAG/His6-tagged Aurora-B (2 to 344 residues)/GST-tagged INCENP preincubated for 30 mins followed by 5FAM-PKA-tide su...				Bioorg Med Chem Lett 28: 3458-3462 (2018) Article DOI: 10.1016/j.bmcl.2018.09.022 BindingDB Entry DOI: 10.7270/Q2X3515K
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50467675 (CHEMBL4280620) Show SMILES CC(=O)c1ccc(OCc2ccccn2)c(c1)-c1ccc2CCNCCc2c1 Show InChI InChI=1S/C24H24N2O2/c1-17(27)19-7-8-24(28-16-22-4-2-3-11-26-22)23(15-19)21-6-5-18-9-12-25-13-10-20(18)14-21/h2-8,11,14-15,25H,9-10,12-13,16H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline R&D Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal His6-tagged SYK expressed in baculovirus expression system using Biotin-AAAEEIYGEI as substrate after 60 m...				Bioorg Med Chem Lett 28: 3458-3462 (2018) Article DOI: 10.1016/j.bmcl.2018.09.022 BindingDB Entry DOI: 10.7270/Q2X3515K
					More data for this Ligand-Target Pair