BDBM50467780 CHEBI:5801::HYDROXYCHLOROQUINE::Hydroxychloroquine::med.21724, Compound 9
SMILES: CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12
InChI Key: InChIKey=XXSMGPRMXLTPCZ-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human)) | BDBM50467780 (CHEBI:5801 | HYDROXYCHLOROQUINE | Hydroxychloroqui...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid UniChem | Article PubMed | 126 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
QBI COVID-19 Research Group (QCRG) Curated by ChEMBL | Assay Description Displacement of [3H]-pentazocin from the Sigma1 receptor | Nature 583: 459-468 (2020) Article DOI: 10.1038/s41586-020-2286-9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma intracellular receptor 2 (Homo sapiens (Human)) | BDBM50467780 (CHEBI:5801 | HYDROXYCHLOROQUINE | Hydroxychloroqui...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid UniChem | Article PubMed | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
QBI COVID-19 Research Group (QCRG) Curated by ChEMBL | Assay Description Displacement of [3H]-DTG from the Sigma2 receptor | Nature 583: 459-468 (2020) Article DOI: 10.1038/s41586-020-2286-9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
1,3-beta-glucan synthase component GLS2 (Saccharomyces cerevisiae) | BDBM50467780 (CHEBI:5801 | HYDROXYCHLOROQUINE | Hydroxychloroqui...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid UniChem | Article PubMed | 2.51E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
QBI COVID-19 Research Group (QCRG) Curated by ChEMBL | Assay Description hERG binding assays: Displacement of [3H]-Dofetilide (5 nM final) from hERG membranes obtained from HEK293 cells | Nature 583: 459-468 (2020) Article DOI: 10.1038/s41586-020-2286-9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human)) | BDBM50467780 (CHEBI:5801 | HYDROXYCHLOROQUINE | Hydroxychloroqui...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid UniChem | Article PubMed | 4.79E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
QBI COVID-19 Research Group (QCRG) Curated by ChEMBL | Assay Description Activity of compound against Muscarinic acetylcholine receptor M3 (CHRM3) by displacement of 3H-QNB | Nature 583: 459-468 (2020) Article DOI: 10.1038/s41586-020-2286-9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M2 and M5 (Homo sapiens (Human)) | BDBM50467780 (CHEBI:5801 | HYDROXYCHLOROQUINE | Hydroxychloroqui...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid UniChem | Article PubMed | 5.13E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
QBI COVID-19 Research Group (QCRG) Curated by ChEMBL | Assay Description Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB | Nature 583: 459-468 (2020) Article DOI: 10.1038/s41586-020-2286-9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M2 and M4 (Homo sapiens (Human)) | BDBM50467780 (CHEBI:5801 | HYDROXYCHLOROQUINE | Hydroxychloroqui...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid UniChem | Article PubMed | 5.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
QBI COVID-19 Research Group (QCRG) Curated by ChEMBL | Assay Description Activity of compound against Muscarinic acetylcholine receptor M4 (CHRM4) by displacement of 3H-QNB | Nature 583: 459-468 (2020) Article DOI: 10.1038/s41586-020-2286-9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2A adrenergic receptor (Homo sapiens) | BDBM50467780 (CHEBI:5801 | HYDROXYCHLOROQUINE | Hydroxychloroqui...) | PDB MMDB B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid UniChem | Article PubMed | 6.46E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
QBI COVID-19 Research Group (QCRG) Curated by ChEMBL | Assay Description Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine | Nature 583: 459-468 (2020) Article DOI: 10.1038/s41586-020-2286-9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human)) | BDBM50467780 (CHEBI:5801 | HYDROXYCHLOROQUINE | Hydroxychloroqui...) | UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid UniChem | Article PubMed | 1.55E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
QBI COVID-19 Research Group (QCRG) Curated by ChEMBL | Assay Description Activity of compound against Muscarinic acetylcholine receptor M1 (CHRM1) by displacement of 3H-QNB | Nature 583: 459-468 (2020) Article DOI: 10.1038/s41586-020-2286-9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adrenergic receptor (Homo sapiens (Human)) | BDBM50467780 (CHEBI:5801 | HYDROXYCHLOROQUINE | Hydroxychloroqui...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid UniChem | Article PubMed | 1.58E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
QBI COVID-19 Research Group (QCRG) Curated by ChEMBL | Assay Description Activity of compound against Alpha 2C (ADRA2C) adrenergic receptor by displacement of [3H]-rauwolscine | Nature 583: 459-468 (2020) Article DOI: 10.1038/s41586-020-2286-9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human)) | BDBM50467780 (CHEBI:5801 | HYDROXYCHLOROQUINE | Hydroxychloroqui...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid UniChem | Article PubMed | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
QBI COVID-19 Research Group (QCRG) Curated by ChEMBL | Assay Description Activity of compound against Muscarinic acetylcholine receptor M5 (CHRM5) by displacement of 3H-QNB | Nature 583: 459-468 (2020) Article DOI: 10.1038/s41586-020-2286-9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adrenergic receptor (Homo sapiens (Human)) | BDBM50467780 (CHEBI:5801 | HYDROXYCHLOROQUINE | Hydroxychloroqui...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid UniChem | Article PubMed | 7.24E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
QBI COVID-19 Research Group (QCRG) Curated by ChEMBL | Assay Description Activity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscine | Nature 583: 459-468 (2020) Article DOI: 10.1038/s41586-020-2286-9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein (Zika virus) | BDBM50467780 (CHEBI:5801 | HYDROXYCHLOROQUINE | Hydroxychloroqui...) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid UniChem | PubMed | 9.23E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Australian National University Curated by ChEMBL | Assay Description Inhibition of Zika virus NS2B-NS3 protease | Bioorg Med Chem Lett 30: (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 9 (Homo sapiens (Human)) | BDBM50467780 (CHEBI:5801 | HYDROXYCHLOROQUINE | Hydroxychloroqui...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
CSIR-Indian Institute of Chemical Biology Curated by ChEMBL | Assay Description Antagonist activity at human TLR9 expressed in HEK-Blue cells assessed as reduction in CpGB-induced NF-kappaB levels after 24 hrs by spectrophotometr... | Eur J Med Chem 159: 187-205 (2018) Article DOI: 10.1016/j.ejmech.2018.09.058 BindingDB Entry DOI: 10.7270/Q2C2504D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiotensin-converting enzyme 2 (Homo sapiens (Human)) | BDBM50467780 (CHEBI:5801 | HYDROXYCHLOROQUINE | Hydroxychloroqui...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 740 | n/a | n/a | n/a | n/a |
University of Bonn | Assay Description This is a review article. | Med Res Rev (2020) Article DOI: 10.1002/med.21724 BindingDB Entry DOI: 10.7270/Q2JS9ST6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3C-like proteinase (MERS-CoV) | BDBM50467780 (CHEBI:5801 | HYDROXYCHLOROQUINE | Hydroxychloroqui...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 8.27E+3 | n/a | n/a | n/a | n/a |
University of Bonn | Assay Description This is a review article. | Med Res Rev (2020) Article DOI: 10.1002/med.21724 BindingDB Entry DOI: 10.7270/Q2JS9ST6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3C-like proteinase (3CL-PRO) (Human SARS coronavirus (SARS-CoV) (Severe acute re...) | BDBM50467780 (CHEBI:5801 | HYDROXYCHLOROQUINE | Hydroxychloroqui...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 7.96E+3 | n/a | n/a | n/a | n/a |
University of Bonn | Assay Description This is a review article. | Med Res Rev (2020) Article DOI: 10.1002/med.21724 BindingDB Entry DOI: 10.7270/Q2JS9ST6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 7 (Homo sapiens (Human)) | BDBM50467780 (CHEBI:5801 | HYDROXYCHLOROQUINE | Hydroxychloroqui...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | 8.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
CSIR-Indian Institute of Chemical Biology Curated by ChEMBL | Assay Description Antagonist activity at human TLR7 expressed in HEK-Blue cells assessed as inhibition of CL264-induced NFkappaB activation by measuring reduction in S... | J Med Chem 63: 4776-4789 (2020) Article DOI: 10.1021/acs.jmedchem.0c00011 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (2019-nCoV) | BDBM50467780 (CHEBI:5801 | HYDROXYCHLOROQUINE | Hydroxychloroqui...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid UniChem | n/a | n/a | 3.58E+6 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 7 (Homo sapiens (Human)) | BDBM50467780 (CHEBI:5801 | HYDROXYCHLOROQUINE | Hydroxychloroqui...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
CSIR-Indian Institute of Chemical Biology Curated by ChEMBL | Assay Description Antagonist activity at human TLR7 expressed in HEK-Blue cells assessed as reduction in CL264-induced NF-kappaB levels after 24 hrs by spectrophotomet... | Eur J Med Chem 159: 187-205 (2018) Article DOI: 10.1016/j.ejmech.2018.09.058 BindingDB Entry DOI: 10.7270/Q2C2504D | |||||||||||
More data for this Ligand-Target Pair |