BDBM50468182 CHEMBL4292047

SMILES: CC(=O)Nc1cc(ccn1)-c1[nH]c2cccnc2c1-c1cccc(C)n1

InChI Key: InChIKey=XPASUDUUTHMDBC-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50468182   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
TGF-beta receptor type II (Homo sapiens (Human))	BDBM50468182 (CHEMBL4292047) Show SMILES CC(=O)Nc1cc(ccn1)-c1[nH]c2cccnc2c1-c1cccc(C)n1 Show InChI InChI=1S/C20H17N5O/c1-12-5-3-6-15(23-12)18-19(25-16-7-4-9-22-20(16)18)14-8-10-21-17(11-14)24-13(2)26/h3-11,25H,1-2H3,(H,21,24,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	730	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research and Development Curated by ChEMBL					Assay Description Inhibition of wild type TGFbetaR2 (unknown origin) kinase domain after 1 hr by HTRF assay				ACS Med Chem Lett 9: 1117-1122 (2018) Article DOI: 10.1021/acsmedchemlett.8b00357 BindingDB Entry DOI: 10.7270/Q2KH0R22
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50468182 (CHEMBL4292047) Show SMILES CC(=O)Nc1cc(ccn1)-c1[nH]c2cccnc2c1-c1cccc(C)n1 Show InChI InChI=1S/C20H17N5O/c1-12-5-3-6-15(23-12)18-19(25-16-7-4-9-22-20(16)18)14-8-10-21-17(11-14)24-13(2)26/h3-11,25H,1-2H3,(H,21,24,26)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research and Development Curated by ChEMBL					Assay Description Inhibition of TGFbetaR1 T204D mutant (unknown origin) kinase domain after 1 hr by HTRF assay				ACS Med Chem Lett 9: 1117-1122 (2018) Article DOI: 10.1021/acsmedchemlett.8b00357 BindingDB Entry DOI: 10.7270/Q2KH0R22
					More data for this Ligand-Target Pair