BDBM50468579 CHEMBL4287262
SMILES: NC(=O)c1ccc(Oc2ccc(cc2)C(O)=O)cc1
InChI Key: InChIKey=FIHJPVBFFYAION-UHFFFAOYSA-N
Data: 12 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Protein mono-ADP-ribosyltransferase PARP4 (Homo sapiens (Human)) | BDBM50468579 (CHEMBL4287262) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oulu Curated by ChEMBL | Assay Description Inhibition of N-terminal His-tagged human ARTD4 (250 to 565 residues) expressed in Escherichia coli Rosetta2 (DE3) using TCEP as substrate after 2.5 ... | Eur J Med Chem 156: 93-102 (2018) Article DOI: 10.1016/j.ejmech.2018.06.047 BindingDB Entry DOI: 10.7270/Q2P271SW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein mono-ADP-ribosyltransferase PARP16 (Homo sapiens (Human)) | BDBM50468579 (CHEMBL4287262) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oulu Curated by ChEMBL | Assay Description Inhibition of N-terminal His-tagged human ARTD15 (1 to 280 residues) expressed in Escherichia coli Rosetta2 (DE3) after 24 hrs in presence of NAD+ | Eur J Med Chem 156: 93-102 (2018) Article DOI: 10.1016/j.ejmech.2018.06.047 BindingDB Entry DOI: 10.7270/Q2P271SW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein mono-ADP-ribosyltransferase PARP12 (Homo sapiens (Human)) | BDBM50468579 (CHEMBL4287262) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oulu Curated by ChEMBL | Assay Description Inhibition of N-terminal His-tagged thioredoxin-fused human ARTD12 (469 to 701 residues) expressed in Escherichia coli Rosetta2 (DE3) after 20 hrs in... | Eur J Med Chem 156: 93-102 (2018) Article DOI: 10.1016/j.ejmech.2018.06.047 BindingDB Entry DOI: 10.7270/Q2P271SW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein mono-ADP-ribosyltransferase PARP15 (Homo sapiens (Human)) | BDBM50468579 (CHEMBL4287262) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oulu Curated by ChEMBL | Assay Description Inhibition of N-terminal His-tagged human ARTD7 (482 to 678 residues) expressed in Escherichia coli Rosetta2 (DE3) using SRPK2 as substrate after 3 h... | Eur J Med Chem 156: 93-102 (2018) Article DOI: 10.1016/j.ejmech.2018.06.047 BindingDB Entry DOI: 10.7270/Q2P271SW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human)) | BDBM50468579 (CHEMBL4287262) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oulu Curated by ChEMBL | Assay Description Inhibition of N-terminal His-tagged human ARTD5 (1030 to 1317 residues) expressed in Escherichia coli Rosetta2 (DE3) using TCEP as substrate after 18... | Eur J Med Chem 156: 93-102 (2018) Article DOI: 10.1016/j.ejmech.2018.06.047 BindingDB Entry DOI: 10.7270/Q2P271SW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein mono-ADP-ribosyltransferase PARP10 (Homo sapiens (Human)) | BDBM50468579 (CHEMBL4287262) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 186 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oulu Curated by ChEMBL | Assay Description Inhibition of C-terminal His-tagged human ARTD10 (809 to 1017 residues) expressed in Escherichia coli Rosetta2 (DE3) using SRPK2 as substrate after 1... | Eur J Med Chem 156: 93-102 (2018) Article DOI: 10.1016/j.ejmech.2018.06.047 BindingDB Entry DOI: 10.7270/Q2P271SW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM50468579 (CHEMBL4287262) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oulu Curated by ChEMBL | Assay Description Inhibition of N-terminal His-tagged human ARTD1 (1 to 1014 residues) expressed in Escherichia coli Rosetta2 (DE3) using activated DNA as substrate af... | Eur J Med Chem 156: 93-102 (2018) Article DOI: 10.1016/j.ejmech.2018.06.047 BindingDB Entry DOI: 10.7270/Q2P271SW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein mono-ADP-ribosyltransferase PARP10 (Homo sapiens (Human)) | BDBM50468579 (CHEMBL4287262) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oulu Curated by ChEMBL | Assay Description Inhibition of C-terminal His-tagged human ARTD10 (809 to 1017 residues) expressed in Escherichia coli Rosetta2 (DE3) using SRPK2 as substrate after 1... | Eur J Med Chem 156: 93-102 (2018) Article DOI: 10.1016/j.ejmech.2018.06.047 BindingDB Entry DOI: 10.7270/Q2P271SW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human)) | BDBM50468579 (CHEMBL4287262) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oulu Curated by ChEMBL | Assay Description Inhibition of N-terminal His-tagged Z-basic-fused human ARTD6 (873 to 1161 residues) expressed in Escherichia coli Rosetta2 (DE3) using TCEP as subst... | Eur J Med Chem 156: 93-102 (2018) Article DOI: 10.1016/j.ejmech.2018.06.047 BindingDB Entry DOI: 10.7270/Q2P271SW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase 2 (Homo sapiens (Human)) | BDBM50468579 (CHEMBL4287262) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oulu Curated by ChEMBL | Assay Description Inhibition of N-terminal His-tagged thioredoxin-fused human ARTD2 (1 to 583 residues) expressed in Escherichia coli Rosetta2 (DE3) using activated DN... | Eur J Med Chem 156: 93-102 (2018) Article DOI: 10.1016/j.ejmech.2018.06.047 BindingDB Entry DOI: 10.7270/Q2P271SW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein mono-ADP-ribosyltransferase PARP14 (Homo sapiens (Human)) | BDBM50468579 (CHEMBL4287262) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oulu Curated by ChEMBL | Assay Description Inhibition of N-terminal His-tagged thioredoxin-fused human ARTD8 (1535 to 1801 residues) expressed in Escherichia coli Rosetta2 (DE3) after 21 hrs i... | Eur J Med Chem 156: 93-102 (2018) Article DOI: 10.1016/j.ejmech.2018.06.047 BindingDB Entry DOI: 10.7270/Q2P271SW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein mono-ADP-ribosyltransferase PARP3 (Homo sapiens (Human)) | BDBM50468579 (CHEMBL4287262) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oulu Curated by ChEMBL | Assay Description Inhibition of N-terminal His-tagged thioredoxin-fused human ARTD3 (1 to 533 residues) expressed in Escherichia coli Rosetta2 (DE3) using DNA as subst... | Eur J Med Chem 156: 93-102 (2018) Article DOI: 10.1016/j.ejmech.2018.06.047 BindingDB Entry DOI: 10.7270/Q2P271SW | |||||||||||
More data for this Ligand-Target Pair |