null
SMILES: FC(F)(F)c1nc(no1)-c1ccc(cc1)N1[C@@H](CCC1=O)c1nc(no1)-c1ccncc1
InChI Key:
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histone deacetylase 6 (Homo sapiens (Human)) | BDBM504687 ((S)-5-(3-(pyridin-4- yl)-1,2,4-oxadiazol- 5-yl)-1-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 7.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description HDAC1 and 6 reagents: FLAG-tagged HDACs 1 and 6 were prepared in-house by protein expression in HEK293F cells followed by anti-FLAG affinity purifica... | Citation and Details BindingDB Entry DOI: 10.7270/Q2DN485Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 8 (Homo sapiens (Human)) | BDBM504687 ((S)-5-(3-(pyridin-4- yl)-1,2,4-oxadiazol- 5-yl)-1-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description HDAC8 reagents: HDAC8 was purchased from Enzo Life Sciences [catalog #BML-SE145]. Assays were performed with buffer containing 20 mM HEPES, pH 8.0 [B... | Citation and Details BindingDB Entry DOI: 10.7270/Q2DN485Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1 (Homo sapiens (Human)) | BDBM504687 ((S)-5-(3-(pyridin-4- yl)-1,2,4-oxadiazol- 5-yl)-1-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 82 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description HDAC1 and 6 reagents: FLAG-tagged HDACs 1 and 6 were prepared in-house by protein expression in HEK293F cells followed by anti-FLAG affinity purifica... | Citation and Details BindingDB Entry DOI: 10.7270/Q2DN485Z | |||||||||||
More data for this Ligand-Target Pair |