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SMILES: FC(F)(F)c1ccc(cc1)-c1cc2nc(-c3ccco3)c(nc2cc1Br)-c1ccco1

InChI Key: InChIKey=IYQYGDYCEUCOEI-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50468963   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM50468963
PNG
(CHEMBL4279307)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc2nc(-c3ccco3)c(nc2cc1Br)-c1ccco1
Show InChI InChI=1S/C23H12BrF3N2O2/c24-16-12-18-17(11-15(16)13-5-7-14(8-6-13)23(25,26)27)28-21(19-3-1-9-30-19)22(29-18)20-4-2-10-31-20/h1-12H
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 516n/an/an/an/a



Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length PI3K p85alpha/p110alpha H1047R mutant (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 a...

Eur J Med Chem 157: 37-49 (2018)


Article DOI: 10.1016/j.ejmech.2018.07.061
BindingDB Entry DOI: 10.7270/Q2ZC85KT
More data for this
Ligand-Target Pair