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SMILES: OC(=O)CCC(=O)Nc1cc(COC(=O)CCC(O)=O)cc(Nc2c3ccccc3nc3ccccc23)c1

InChI Key: InChIKey=UYAHPJAYAPUFBJ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50470370   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
DNA topoisomerase 2-alpha/2-beta


(Homo sapiens (Human))		BDBM50470370
PNG
(CHEMBL109468)
Show SMILES OC(=O)CCC(=O)Nc1cc(COC(=O)CCC(O)=O)cc(Nc2c3ccccc3nc3ccccc23)c1
Show InChI InChI=1S/C28H25N3O7/c32-24(9-10-25(33)34)29-18-13-17(16-38-27(37)12-11-26(35)36)14-19(15-18)30-28-20-5-1-3-7-22(20)31-23-8-4-2-6-21(23)28/h1-8,13-15H,9-12,16H2,(H,29,32)(H,30,31)(H,33,34)(H,35,36)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Sloan-Kettering Institute for Cancer Research

Curated by ChEMBL


Assay Description
In vitro 50% inhibition of topoisomerase II mediated k-DNA decatenation

J Med Chem 38: 3226-35 (1995)


Article DOI: 10.1021/jm00017a006
BindingDB Entry DOI: 10.7270/Q2XS5Z3R
More data for this
Ligand-Target Pair