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SMILES: Clc1cccc(c1)-c1nn(Cc2ccncc2)c(=O)c2cccnc12

InChI Key: InChIKey=COLQUUDNEIJASV-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50471096   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50471096 (CHEMBL414613 | RS-14491) Show SMILES Clc1cccc(c1)-c1nn(Cc2ccncc2)c(=O)c2cccnc12 Show InChI InChI=1S/C19H13ClN4O/c20-15-4-1-3-14(11-15)17-18-16(5-2-8-22-18)19(25)24(23-17)12-13-6-9-21-10-7-13/h1-11H,12H2	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibitory activity against cGMP inhibited Phosphodiesterase 3, isolated from guinea pig ventricular tissue				J Med Chem 41: 4021-35 (1998) Article DOI: 10.1021/jm981012m BindingDB Entry DOI: 10.7270/Q2TM7DV3
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C (Rattus norvegicus)	BDBM50471096 (CHEMBL414613 | RS-14491) Show SMILES Clc1cccc(c1)-c1nn(Cc2ccncc2)c(=O)c2cccnc12 Show InChI InChI=1S/C19H13ClN4O/c20-15-4-1-3-14(11-15)17-18-16(5-2-8-22-18)19(25)24(23-17)12-13-6-9-21-10-7-13/h1-11H,12H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Affinity for the high affinity rolipram binding site of phosphodiesterase (PDE IV) by [3H]rolipram displacement.				J Med Chem 41: 4021-35 (1998) Article DOI: 10.1021/jm981012m BindingDB Entry DOI: 10.7270/Q2TM7DV3
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50471096 (CHEMBL414613 | RS-14491) Show SMILES Clc1cccc(c1)-c1nn(Cc2ccncc2)c(=O)c2cccnc12 Show InChI InChI=1S/C19H13ClN4O/c20-15-4-1-3-14(11-15)17-18-16(5-2-8-22-18)19(25)24(23-17)12-13-6-9-21-10-7-13/h1-11H,12H2	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	56	n/a	n/a	n/a	n/a	n/a	n/a
Dipartimento di Scienze Farmaceutiche, Firenze, Italy. Curated by ChEMBL					Assay Description Inhibition of guinea pig ventricular Phosphodiesterase 4				J Med Chem 40: 1417-21 (1997) Article DOI: 10.1021/jm970105l BindingDB Entry DOI: 10.7270/Q2RX9FSV
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C (Rattus norvegicus)	BDBM50471096 (CHEMBL414613 | RS-14491) Show SMILES Clc1cccc(c1)-c1nn(Cc2ccncc2)c(=O)c2cccnc12 Show InChI InChI=1S/C19H13ClN4O/c20-15-4-1-3-14(11-15)17-18-16(5-2-8-22-18)19(25)24(23-17)12-13-6-9-21-10-7-13/h1-11H,12H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a	n/a
Dipartimento di Scienze Farmaceutiche, Firenze, Italy. Curated by ChEMBL					Assay Description Displacement of [3H]rolipram from rat brain membranes				J Med Chem 40: 1417-21 (1997) Article DOI: 10.1021/jm970105l BindingDB Entry DOI: 10.7270/Q2RX9FSV
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50471096 (CHEMBL414613 | RS-14491) Show SMILES Clc1cccc(c1)-c1nn(Cc2ccncc2)c(=O)c2cccnc12 Show InChI InChI=1S/C19H13ClN4O/c20-15-4-1-3-14(11-15)17-18-16(5-2-8-22-18)19(25)24(23-17)12-13-6-9-21-10-7-13/h1-11H,12H2	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Dipartimento di Scienze Farmaceutiche, Firenze, Italy. Curated by ChEMBL					Assay Description Inhibition of guinea pig ventricular Phosphodiesterase 3				J Med Chem 40: 1417-21 (1997) Article DOI: 10.1021/jm970105l BindingDB Entry DOI: 10.7270/Q2RX9FSV
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50471096 (CHEMBL414613 | RS-14491) Show SMILES Clc1cccc(c1)-c1nn(Cc2ccncc2)c(=O)c2cccnc12 Show InChI InChI=1S/C19H13ClN4O/c20-15-4-1-3-14(11-15)17-18-16(5-2-8-22-18)19(25)24(23-17)12-13-6-9-21-10-7-13/h1-11H,12H2	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	56	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase 4 isolated from guinea pig ventricular tissue				J Med Chem 41: 4021-35 (1998) Article DOI: 10.1021/jm981012m BindingDB Entry DOI: 10.7270/Q2TM7DV3
					More data for this Ligand-Target Pair