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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'cAMP-specific 3',5'-cyclic phosphodiesterase 4C' and Ligand = 'BDBM50471096'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)		BDBM50471096
PNG
(CHEMBL414613 | RS-14491)
Show SMILES Clc1cccc(c1)-c1nn(Cc2ccncc2)c(=O)c2cccnc12
Show InChI InChI=1S/C19H13ClN4O/c20-15-4-1-3-14(11-15)17-18-16(5-2-8-22-18)19(25)24(23-17)12-13-6-9-21-10-7-13/h1-11H,12H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 4.80n/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche, Firenze, Italy.

Curated by ChEMBL


Assay Description
Displacement of [3H]rolipram from rat brain membranes

J Med Chem 40: 1417-21 (1997)


Article DOI: 10.1021/jm970105l
BindingDB Entry DOI: 10.7270/Q2RX9FSV
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)		BDBM50471096
PNG
(CHEMBL414613 | RS-14491)
Show SMILES Clc1cccc(c1)-c1nn(Cc2ccncc2)c(=O)c2cccnc12
Show InChI InChI=1S/C19H13ClN4O/c20-15-4-1-3-14(11-15)17-18-16(5-2-8-22-18)19(25)24(23-17)12-13-6-9-21-10-7-13/h1-11H,12H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 4.80n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Affinity for the high affinity rolipram binding site of phosphodiesterase (PDE IV) by [3H]rolipram displacement.

J Med Chem 41: 4021-35 (1998)


Article DOI: 10.1021/jm981012m
BindingDB Entry DOI: 10.7270/Q2TM7DV3
More data for this
Ligand-Target Pair