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BDBM50473096 CHEMBL434234

SMILES: C1Nc2cc[n+](Cc3ccc(Cc4ccc(C[n+]5ccc(NCc6ccc(cc6)-c6ccc1cc6)c1ccccc51)cc4)cc3)c1ccccc21

InChI Key: InChIKey=JXTPJASKLIIGJS-UPGPOWGVSA-P

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50473096   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Small conductance calcium-activated potassium channel


(Rattus norvegicus-RAT-Rattus norvegicus (Rat))		BDBM50473096
PNG
(CHEMBL434234)
Show SMILES C1Nc2cc[n+](Cc3ccc(Cc4ccc(C[n+]5ccc(NCc6ccc(cc6)-c6ccc1cc6)c1ccccc51)cc4)cc3)c1ccccc21
Show InChI InChI=1S/C47H38N4/c1-3-7-46-42(5-1)44-25-27-50(46)32-38-13-9-34(10-14-38)29-35-11-15-39(16-12-35)33-51-28-26-45(43-6-2-4-8-47(43)51)49-31-37-19-23-41(24-20-37)40-21-17-36(18-22-40)30-48-44/h1-28H,29-33H2/p+2/b48-44+,49-45+
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 280n/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...

J Med Chem 43: 420-31 (2000)


Article DOI: 10.1021/jm9902537
BindingDB Entry DOI: 10.7270/Q21V5HQ2
More data for this
Ligand-Target Pair