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SMILES: OC12CCC(Cc3ccccc3C1)C2NS(=O)(=O)c1ccc(Cl)s1

InChI Key: InChIKey=LRKSZTJQEVWHDS-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50477968   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Presenilin-1


(Homo sapiens (Human))		BDBM50477968
PNG
(CHEMBL256616)
Show SMILES OC12CCC(Cc3ccccc3C1)C2NS(=O)(=O)c1ccc(Cl)s1 |TLB:10:11:13:2.3,THB:14:13:2.3:12.5.6.11|
Show InChI InChI=1S/C17H18ClNO3S2/c18-14-5-6-15(23-14)24(21,22)19-16-12-7-8-17(16,20)10-13-4-2-1-3-11(13)9-12/h1-6,12,16,19-20H,7-10H2
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PC cid
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UniChem
Article
PubMed
n/an/a 23n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human gamma secretase in human SHSY5Y cells

Bioorg Med Chem Lett 18: 375-9 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.057
BindingDB Entry DOI: 10.7270/Q29G5QKF
More data for this
Ligand-Target Pair