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SMILES: [#6]\[#6](-[#6])=[#6]/[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6](-[#6](-[#6]-[#6](-[#8])=O)-[#6](-[#8])=O)-c1nccn1-[#6]

InChI Key: InChIKey=JRUPZAMPCOXFPV-WGUKNHOESA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50481617   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50481617
PNG
(CHEMBL590148)
Show SMILES [#6]\[#6](-[#6])=[#6]/[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6](-[#6](-[#6]-[#6](-[#8])=O)-[#6](-[#8])=O)-c1nccn1-[#6]
Show InChI InChI=1S/C23H34N2O4/c1-16(2)8-6-9-17(3)10-7-11-18(4)14-19(22-24-12-13-25(22)5)20(23(28)29)15-21(26)27/h8,10,12-14,19-20H,6-7,9,11,15H2,1-5H3,(H,26,27)(H,28,29)/b17-10+,18-14+
PDB
MMDB

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PC cid
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n/an/a 1.20E+4n/an/an/an/an/an/a



Centre de Recherche de Gif-sur-Yvette

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FTase by fluorescent-based assay

Bioorg Med Chem 18: 543-56 (2010)


Article DOI: 10.1016/j.bmc.2009.12.017
BindingDB Entry DOI: 10.7270/Q2VM4G37
More data for this
Ligand-Target Pair