BindingDB PrimarySearch

BDBM50482 (5Z)-5-(3-bromo-4,5-dihydroxy-benzylidene)-2-(p-tolyl)-2-thiazolin-4-one::(5Z)-5-[(3-bromo-4,5-dihydroxyphenyl)methylidene]-2-(4-methylphenyl)-1,3-thiazol-4-one::(5Z)-5-[(3-bromo-4,5-dihydroxyphenyl)methylidene]-2-(4-methylphenyl)-4-thiazolone::(5Z)-5-[[3-bromanyl-4,5-bis(oxidanyl)phenyl]methylidene]-2-(4-methylphenyl)-1,3-thiazol-4-one::5-(3-bromo-4,5-dihydroxybenzylidene)-2-(4-methylphenyl)-1,3-thiazol-4(5H)-one::MLS000676730::SMR000298379::cid_5730111

SMILES: Cc1ccc(cc1)C1=NC(=O)\C(S1)=C\c1cc(O)c(O)c(Br)c1

InChI Key: InChIKey=MUQKQSJCEVWZCU-ZSOIEALJSA-N

Data: 3 IC50 1 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50482
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Induced myeloid leukemia cell differentiation protein Mcl-1 (Homo sapiens (Human))	BDBM50482 ((5Z)-5-(3-bromo-4,5-dihydroxy-benzylidene)-2-(p-to...) Show SMILES Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	767	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Molecular Libraries Screening Center Curated by PubChem BioAssay					Assay Description NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Nikolovska-Coleska, Univer...				PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q23X8539
					More data for this Ligand-Target Pair
Dengue virus type 2 NS3 protein (Dengue virus 2)	BDBM50482 ((5Z)-5-(3-bromo-4,5-dihydroxy-benzylidene)-2-(p-to...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.94E+3	n/a	n/a	n/a	n/a	n/a	n/a
Queensland University of Technology Curated by ChEMBL					Assay Description Inhibition of DENV2 NS2B-NS3 serine protease expressed using Benzoyl-Nle-Lys-Arg-Arg-AMC as substrate measured preincubated for 3 mins followed by su...				Eur J Med Chem 176: 431-455 (2019) Article DOI: 10.1016/j.ejmech.2019.05.010
Queensland University of Technology Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50482 ((5Z)-5-(3-bromo-4,5-dihydroxy-benzylidene)-2-(p-to...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Second Military Medical University Curated by ChEMBL					Assay Description Inhibition of SYK (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured after 25 m...				Bioorg Med Chem Lett 27: 1776-1779 (2017) Article DOI: 10.1016/j.bmcl.2017.02.060 BindingDB Entry DOI: 10.7270/Q2H41TQC
Second Military Medical University Curated by ChEMBL					More data for this Ligand-Target Pair
large T antigen (Simian virus 40)	BDBM50482 ((5Z)-5-(3-bromo-4,5-dihydroxy-benzylidene)-2-(p-to...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a
Southern Research Specialized Biocontainment Screening Center Curated by PubChem BioAssay					Assay Description Southern Research's Specialized Biocontainment Screening Center (SRSBSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Librarie...				PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2ZK5F47
					More data for this Ligand-Target Pair