null

SMILES: CN(C)c1nc2c(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)c(F)c3)ccnc2[nH]1

InChI Key: InChIKey=NRTMTKOKWUMVGK-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50482485   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50482485 (CHEMBL1213754) Show SMILES CN(C)c1nc2c(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)c(F)c3)ccnc2[nH]1 Show InChI InChI=1S/C22H17F5N6O2/c1-33(2)20-31-18-17(7-8-28-19(18)32-20)35-12-4-6-15(14(24)10-12)29-21(34)30-16-9-11(22(25,26)27)3-5-13(16)23/h3-10H,1-2H3,(H,28,31,32)(H2,29,30,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human WM266.4 cells				J Med Chem 53: 5639-55 (2010) Article DOI: 10.1021/jm100383b BindingDB Entry DOI: 10.7270/Q22V2JZS
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50482485 (CHEMBL1213754) Show SMILES CN(C)c1nc2c(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)c(F)c3)ccnc2[nH]1 Show InChI InChI=1S/C22H17F5N6O2/c1-33(2)20-31-18-17(7-8-28-19(18)32-20)35-12-4-6-15(14(24)10-12)29-21(34)30-16-9-11(22(25,26)27)3-5-13(16)23/h3-10H,1-2H3,(H,28,31,32)(H2,29,30,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of B-Raf V600E mutant				J Med Chem 53: 5639-55 (2010) Article DOI: 10.1021/jm100383b BindingDB Entry DOI: 10.7270/Q22V2JZS
					More data for this Ligand-Target Pair