null

SMILES: FC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)cc2)ccc1Cl

InChI Key: InChIKey=WVZQOIFRERLBHI-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50482486   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50482486 (CHEMBL1213821) Show SMILES FC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)cc2)ccc1Cl Show InChI InChI=1S/C21H13ClF3N5O3/c22-15-6-3-12(9-14(15)21(23,24)25)29-20(32)28-11-1-4-13(5-2-11)33-16-7-8-26-19-18(16)27-10-17(31)30-19/h1-10H,(H,26,30,31)(H2,28,29,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.89E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human WM266.4 cells				J Med Chem 53: 5639-55 (2010) Article DOI: 10.1021/jm100383b BindingDB Entry DOI: 10.7270/Q22V2JZS
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50482486 (CHEMBL1213821) Show SMILES FC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)cc2)ccc1Cl Show InChI InChI=1S/C21H13ClF3N5O3/c22-15-6-3-12(9-14(15)21(23,24)25)29-20(32)28-11-1-4-13(5-2-11)33-16-7-8-26-19-18(16)27-10-17(31)30-19/h1-10H,(H,26,30,31)(H2,28,29,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of B-Raf V600E mutant				J Med Chem 53: 5639-55 (2010) Article DOI: 10.1021/jm100383b BindingDB Entry DOI: 10.7270/Q22V2JZS
					More data for this Ligand-Target Pair