null

SMILES: CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4nc(N)c(=O)[nH]c34)c3ccccc23)n(n1)-c1ccccc1

InChI Key: InChIKey=GZLUSKKVLZNIIS-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50482518   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50482518 (CHEMBL1214382) Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4nc(N)c(=O)[nH]c34)c3ccccc23)n(n1)-c1ccccc1 Show InChI InChI=1S/C31H28N8O3/c1-31(2,3)24-17-25(39(38-24)18-9-5-4-6-10-18)35-30(41)34-21-13-14-22(20-12-8-7-11-19(20)21)42-23-15-16-33-28-26(23)36-29(40)27(32)37-28/h4-17H,1-3H3,(H,36,40)(H2,32,33,37)(H2,34,35,41)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human WM266.4 cells				J Med Chem 53: 5639-55 (2010) Article DOI: 10.1021/jm100383b BindingDB Entry DOI: 10.7270/Q22V2JZS
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50482518 (CHEMBL1214382) Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4nc(N)c(=O)[nH]c34)c3ccccc23)n(n1)-c1ccccc1 Show InChI InChI=1S/C31H28N8O3/c1-31(2,3)24-17-25(39(38-24)18-9-5-4-6-10-18)35-30(41)34-21-13-14-22(20-12-8-7-11-19(20)21)42-23-15-16-33-28-26(23)36-29(40)27(32)37-28/h4-17H,1-3H3,(H,36,40)(H2,32,33,37)(H2,34,35,41)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	405	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of B-Raf V600E mutant				J Med Chem 53: 5639-55 (2010) Article DOI: 10.1021/jm100383b BindingDB Entry DOI: 10.7270/Q22V2JZS
					More data for this Ligand-Target Pair