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SMILES: CCCCCN1CCCn2c1nnc2-c1ccc(c(OC)c1)-n1cnc(C)c1

InChI Key: InChIKey=ADXDHTWGGBEMJF-UHFFFAOYSA-N

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50483275   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Presenilin-1


(Homo sapiens (Human))		BDBM50483275
PNG
(CHEMBL1643431)
Show SMILES CCCCCN1CCCn2c1nnc2-c1ccc(c(OC)c1)-n1cnc(C)c1
Show InChI InChI=1S/C21H28N6O/c1-4-5-6-10-25-11-7-12-27-20(23-24-21(25)27)17-8-9-18(19(13-17)28-3)26-14-16(2)22-15-26/h8-9,13-15H,4-7,10-12H2,1-3H3
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.41E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of gamma secretase-mediated amyloid beta42 production in HEK293 cells by sandwich immunoassay

Bioorg Med Chem Lett 21: 664-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.012
BindingDB Entry DOI: 10.7270/Q2930X12
More data for this
Ligand-Target Pair