Found 4 hits for monomerid = 50484223 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50484223
(CHEMBL1822241)Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]nc(Br)c3c2)c1F Show InChI InChI=1S/C16H14BrF2N5O3S/c1-2-5-28(26,27)24-11-4-3-10(18)12(13(11)19)16(25)21-8-6-9-14(17)22-23-15(9)20-7-8/h3-4,6-7,24H,2,5H2,1H3,(H,21,25)(H,20,22,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 260 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma
Curated by ChEMBL
| Assay Description Inhibition of B-Raf V600E mutant-mediated Erk phosphorylation in human A375 cells after 1 hr by fluorescence analysis |
ACS Med Chem Lett 2: 342-7 (2011)
Article DOI: 10.1021/ml200025q BindingDB Entry DOI: 10.7270/Q2H134VM |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50484223
(CHEMBL1822241)Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]nc(Br)c3c2)c1F Show InChI InChI=1S/C16H14BrF2N5O3S/c1-2-5-28(26,27)24-11-4-3-10(18)12(13(11)19)16(25)21-8-6-9-14(17)22-23-15(9)20-7-8/h3-4,6-7,24H,2,5H2,1H3,(H,21,25)(H,20,22,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
ArrayBioPharma
Curated by ChEMBL
| Assay Description Inhibition of full length B-Raf V600E mutant |
Bioorg Med Chem Lett 21: 5533-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.097 BindingDB Entry DOI: 10.7270/Q28K7CX8 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50484223
(CHEMBL1822241)Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]nc(Br)c3c2)c1F Show InChI InChI=1S/C16H14BrF2N5O3S/c1-2-5-28(26,27)24-11-4-3-10(18)12(13(11)19)16(25)21-8-6-9-14(17)22-23-15(9)20-7-8/h3-4,6-7,24H,2,5H2,1H3,(H,21,25)(H,20,22,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma
Curated by ChEMBL
| Assay Description Inhibition of B-Raf V600E mutant-mediated Erk phosphorylation in human MALME-3M cells after 1 hr by fluorescence analysis |
ACS Med Chem Lett 2: 342-7 (2011)
Article DOI: 10.1021/ml200025q BindingDB Entry DOI: 10.7270/Q2H134VM |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50484223
(CHEMBL1822241)Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]nc(Br)c3c2)c1F Show InChI InChI=1S/C16H14BrF2N5O3S/c1-2-5-28(26,27)24-11-4-3-10(18)12(13(11)19)16(25)21-8-6-9-14(17)22-23-15(9)20-7-8/h3-4,6-7,24H,2,5H2,1H3,(H,21,25)(H,20,22,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma
Curated by ChEMBL
| Assay Description Inhibition of full length human B-Raf V600E mutant expressed in baculovirus infected insect cells assessed as [gamma-33P]incorporation into MEK after... |
ACS Med Chem Lett 2: 342-7 (2011)
Article DOI: 10.1021/ml200025q BindingDB Entry DOI: 10.7270/Q2H134VM |
More data for this Ligand-Target Pair | |