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BDBM50485691 CHEMBL2152880

SMILES: [H][C@]12O[C@]([H])(C[C@@H](C)[C@]1([H])[C@@]1(C)CC[C@@]34C[C@@]33CC[C@H](O[C@@]5([H])CN(CCO5)C5COC5)C(C)(C)[C@]3([H])CC[C@@]4([H])[C@]1(C)[C@H]2O)[C@H](OC(C)=O)C(C)(C)O

InChI Key: InChIKey=OFYAAQBYMVYTQQ-AFWPQRMSSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50485691   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Presenilin-1


(Homo sapiens (Human))		BDBM50485691
PNG
(CHEMBL2152880)
Show SMILES [H][C@]12O[C@]([H])(C[C@@H](C)[C@]1([H])[C@@]1(C)CC[C@@]34C[C@@]33CC[C@H](O[C@@]5([H])CN(CCO5)C5COC5)C(C)(C)[C@]3([H])CC[C@@]4([H])[C@]1(C)[C@H]2O)[C@H](OC(C)=O)C(C)(C)O |r|
Show InChI InChI=1S/C39H63NO8/c1-22-17-25(33(35(5,6)43)46-23(2)41)47-31-30(22)36(7)13-14-39-21-38(39)12-11-28(48-29-18-40(15-16-45-29)24-19-44-20-24)34(3,4)26(38)9-10-27(39)37(36,8)32(31)42/h22,24-33,42-43H,9-21H2,1-8H3/t22-,25-,26+,27+,28+,29+,30+,31+,32+,33+,36-,37-,38-,39+/m1/s1
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>2.00E+4n/an/an/an/an/an/a



Satori Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of gamma-secretase-mediated notch processing in human SUP-T1 cells after 1 hr by luminescent assay

ACS Med Chem Lett 3: 908-13 (2012)


Article DOI: 10.1021/ml300256p
BindingDB Entry DOI: 10.7270/Q29G5QPS
More data for this
Ligand-Target Pair